Coordinate regulation of purine nucleoside phosphorylase and xanthine dehydrogenase levels in chick liver

Lee, P.C.; Nickels, Janet S.; Fisher, James R.

doi:10.1016/0003-9861(73)90560-2

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…The de novo synthesis of purine nucleotides is greatly enhanced, and the levels of hypoxanthine and xanthine are considerably increased (Rosenbloom et al, 1967; Balis et al, 1967). It has been postulated (Lee et al, 1973) that there is so~e coordinate control of the activities of the enzymes participating in the purine metabolic pathway; this control is suggested to be related to the levels of the intermediate metabolites. Barankiewicz et ale (1975) have found that in the mammary glands of mice the direction of changes in hypoxanthine-guanine phosphoribosyltransferase and purine-nucleoside phosphorylase activities was the same for both enzymes, i.e.…”

Section: Discussionmentioning

confidence: 99%

Purine Metabolism in Man—II

Rapado¹,

Watts²,

Bruyn³

1977

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International Symposium on Purine Metabolism in Man, 2d, Baden, Austria, 1976. Purine metabolism in man, II. (Advances in experimental medicine and biology; v. 76) Includes index. CONTENTS: Pt. A. Regulation of pathways and enzyme defects.-Pt. B. Physiology, pharmacology, and clinical aspects. 1. Purine metabolism-Congresses. 2. Uric acid metabolism-Congresses. 3. Metabolism, Inborn errors of-Congresses. I. Miiller, Mathias M. II. Kaiser, Erich, Dr. med. All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher We wish to acknowledge the support of the Dean

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Section: Discussionmentioning

confidence: 99%

Purine Metabolism in Man—II

Rapado¹,

Watts²,

Bruyn³

1977

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“…The following observations are consistent with this model. (1) Dietary protein or amino acids increase the hepatic levels of xanthine dehydrogenase [1,3,4,7,11,12,19,24,25,27,29], purine nucleoside phosphorylase [7,11,29], cytosol 5'-nucleotidase [7], tyrosine aminotransferase [29], glutamine-PRPP-amidotransferase [8], and tryptophan pyrrolase [2]. The increased level of xanthine dehydrogenase is due to increased enzyme synthesis (this paper).…”

Section: Discussionmentioning

confidence: 99%

Regulation of Nitrogen Catabolic Enzymes in Chick Liver - Effects of Amino Acids

Fisher¹,

Stewart²,

Wu³

et al. 1976

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It is well-known that in the chick, dietary protein increases the levels of several hepatic enzymes that are involved in nitrogen metabolism and excretion. However, the biochemical mechanism of this response is essentially unknown.The experiments presented in this paper show that the chick is responding to α-amino nitrogen and not to any specific amino acid. Furthermore, it is shown that this system responds to endogenous sources of nitrogen as well as dietary protein and that the xanthine dehydrogenase response involves regulation of enzyme synthesis without changing the rate of degradation.

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Purine-Nucleoside Phosphorylase and Adenosine Aminohydrolase Activities in Fibroblasts with the Leschnyhan Mutation

Barankiewicz

Jeżewska

1977

Purine Metabolism in Man—II

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Coordinate regulation of purine nucleoside phosphorylase and xanthine dehydrogenase levels in chick liver

Cited by 7 publications

References 13 publications

Purine Metabolism in Man—II

Purine Metabolism in Man—II

Regulation of Nitrogen Catabolic Enzymes in Chick Liver - Effects of Amino Acids

Purine-Nucleoside Phosphorylase and Adenosine Aminohydrolase Activities in Fibroblasts with the Leschnyhan Mutation

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