From harmonic compensation to interface with renewable energy sources, active filters are capable to improve power quality, increase the reliability of the power grid, and contribute to make feasible the implementation of decentralized microgrids. In this scenario, this chapter provides a discussion involving new trends on distribution power grids, with active power filters playing an important key role. Considering the aforementioned explanation, part of the chapter covers active filter applications for power grids. In sequence, we discuss time domain control algorithms to identify power quality disturbances or other problems that may compromise the power grid reliability, with simulation results to evaluate the performance of the active filters for compensating power quality problems under transient-and steady-state conditions. Next, we discuss the integration of active filters with renewable energy sources (RENs) including a brief explanation of maximum power point tracking (MPPT) algorithms and other controllers considering a decentralized microgrid scenario with several active filters connected at the same grid circuit.