Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics
Gabrielle Rabadam,
Camilla Wibrand,
Emily Flynn
et al.
Abstract:Juvenile Dermatomyositis (JDM) is one of several childhood-onset autoimmune disorders characterized by a type I interferon response and autoantibodies. Treatment options are limited due to incomplete understanding of how the disease emerges from dysregulated cell states across the immune system. We therefore investigated the blood of JDM patients at different stages of disease activity using single-cell transcriptomics paired with surface protein expression. By immunophenotyping peripheral blood mononuclear ce… Show more
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