Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Tass, Peter A.; Li, Qin; Hauptmann, Christian; Doveró, Sandra; Bézard, Erwan; Boraud, Thomas; Meissner, Wassilios G.

doi:10.1002/ana.23663

Cited by 254 publications

(294 citation statements)

References 20 publications

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“…CR stimulation moves the neuronal population from a pathological attractor (with strong synaptic connectivity and neuronal synchrony) to a more physiological attractor (characterized by reduced synaptic connectivity and neuronal synchrony), in this way inducing cumulative, long-lasting, sustained desynchronizing effects [71][72][73]. These computational predictions were verified both pre-clinically and clinically: long-lasting, sustained and cumulative therapeutic effects of CR-DBS were demonstrated in parkinsonian monkeys [74,75]. Long-lasting desynchronizing and therapeutic effects of CR-DBS were shown in patients with Parkinson's disease [76].…”

Section: Discussionmentioning

confidence: 65%

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Pyragas¹,

Tass²

2017

Lith. J. Phys.

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We analyze the influence of high-frequency current stimulation on spontaneous neuronal activity and show that it may cause a death of spontaneous low-frequency oscillations. We demonstrate the universality of this effect for typical neuron models such as FitzHugh-Nagumo, Morris-Lecar, and Hodgkin-Huxley neurons as well as for the normal form of the supercritical Hopf bifurcation. Using a multiple scale method we separate the solutions of the neuron equations into slow and fast components and derive averaged equations for the slow components. The mechanism of suppression of neuronal activity is explained by an analysis of the bifurcations in the averaged equations governing the dynamics of the slow motion. Our results may contribute to the understanding of therapeutic effects of high-frequency deep brain stimulation, the golden standard for the treatment of medically refractory patients suffering from Parkinson's disease. Furthermore, our study enables hypotheses concerning possible improvements of high-frequency deep brain stimulation.

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Section: Discussionmentioning

confidence: 65%

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Pyragas¹,

Tass²

2017

Lith. J. Phys.

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“…The combined results of Smolders et al related to DBS effects on phase stability and de Hemptinne et al showing a DBS-related decrease in PAC at rest and during movement (de Hemptinne et al 2015) suggest that modulation of PAC is a possible mechanism causing network desynchronization. Network desynchronization by disruption of phase relationships with coordinated reset stimulation is a concept that has been pioneered by Tass and colleagues, who showed remarkable efficacy of this approach in a study of three parkinsonian monkeys (Tass et al 2012). How this desynchronization leads to clinical improvement is still not clear, and the details are likely different across disorders and DBS targets.…”

Section: Discussionmentioning

confidence: 99%

Network effects of deep brain stimulation

Alhourani

McDowell

Randazzo

et al. 2015

Journal of Neurophysiology

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The ability to differentially alter specific brain functions via deep brain stimulation (DBS) represents a monumental advance in clinical neuroscience, as well as within medicine as a whole. Despite the efficacy of DBS in the treatment of movement disorders, for which it is often the gold-standard therapy when medical management becomes inadequate, the mechanisms through which DBS in various brain targets produces therapeutic effects is still not well understood. This limited knowledge is a barrier to improving efficacy and reducing side effects in clinical brain stimulation. A field of study related to assessing the network effects of DBS is gradually emerging that promises to reveal aspects of the underlying pathophysiology of various brain disorders and their response to DBS that will be critical to advancing the field. This review summarizes the nascent literature related to network effects of DBS measured by cerebral blood flow and metabolic imaging, functional imaging, and electrophysiology (scalp and intracranial electroencephalography and magnetoencephalography) in order to establish a framework for future studies. deep brain stimulation; electrocorticography; magnetoencephalography DEEP BRAIN STIMULATION (DBS) provides a unique opportunity for further understanding of healthy and aberrant human brain function. DBS is the only paradigm in which specific deep brain regions may be manipulated through focal electrical stimulation while simultaneously recording brain activity. An emerging field of study has begun to elucidate how different DBS targets modulate network activity in connected brain regions.

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“…A related effort is that of developing stimulators that would allow the use of stimulation parameters that may desynchronize circuit activities [e.g., 332,333] by stimulating with stimulation patterns that involve (in predetermined temporal sequences) multiple contacts in the stimulated area (Bcoordinated reset^stimulation). With regard to the disorders mentioned in this article, this approach has been used with some success in preliminary studies in MPTP-treated monkeys and in patients with PD [333,334]. In the patient study, coordinated reset stimulation was carried out for 2 short daily sessions over a period of 3 days.…”

Section: Technical Developments and Future Of Neuromodulationmentioning

confidence: 99%

Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?

2016

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Deep brain stimulation (DBS) is highly effective for both hypo-and hyperkinetic movement disorders of basal ganglia origin. The clinical use of DBS is, in part, empiric, based on the experience with prior surgical ablative therapies for these disorders, and, in part, driven by scientific discoveries made decades ago. In this review, we consider anatomical and functional concepts of the basal ganglia relevant to our understanding of DBS mechanisms, as well as our current understanding of the pathophysiology of two of the most commonly DBS-treated conditions, Parkinson's disease and dystonia. Finally, we discuss the proposed mechanism(s) of action of DBS in restoring function in patients with movement disorders. The signs and symptoms of the various disorders appear to result from signature disordered activity in the basal ganglia output, which disrupts the activity in thalamocortical and brainstem networks. The available evidence suggests that the effects of DBS are strongly dependent on targeting sensorimotor portions of specific nodes of the basal gangliathalamocortical motor circuit, that is, the subthalamic nucleus and the internal segment of the globus pallidus. There is little evidence to suggest that DBS in patients with movement disorders restores normal basal ganglia functions (e.g., their role in movement or reinforcement learning). Instead, it appears that high-frequency DBS replaces the abnormal basal ganglia output with a more tolerable pattern, which helps to restore the functionality of downstream networks.

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Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Cited by 254 publications

References 20 publications

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Network effects of deep brain stimulation

Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality?

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