Coordination abilities of N-terminal fragments of α-synuclein towards copper(II) ions: A combined potentiometric and spectroscopic study

Copper effective binding with 32–62 and 94–125 peptide fragments of histone H2B

“…However, the peptide was considered as an H 3 L ligand and the protonation constants of Glu, Asp and His ionization sites could be determined. It should be noted, that all calculated values are in agreement with the corresponding values of peptides containing Glu, Lys, Asp and His residues in their sequences [43,44].…”

Synthesis, physico-chemical properties and complexing abilities of new amphiphilic ligands from d-galacturonic acid

“…The complex was EPR silent in methanol solution, its magnetic susceptibility was measured at 298 K and gave a l b value of 1.02 MB less than those expected for mononuclear copper complexes. The comparison of spectroscopic data with those of similar complexes reported by several authors for copper-peptide systems [42][43][44][45] led us to propose a relative structure for the dinuclear species. As shown in Figure 3, copper centers are coordinated by the nitrogen atoms of the pyridine moieties and the neighboring deprotonated nitrogen atoms of the amide functions, to form five-membered chelate rings.…”

Copper(I/II), α/β‐Synuclein and Amyloid‐β: Menage à Trois?

“…Most of the reportso na S1-15a re in about the same rangethat is, 10 À9 to 10 À10 m-again with as lightly stronger affinity of the full-length protein than of aS1-15, mostl ikelyd ue to the binding by His50. [33][34][35] From the coordination chemistry point of view it is interesting to note that the two quite different equatorial binding modes result in very similar affinities at pH 7.4. Although in both cases Cu II is bound to the N-terminal amine (Asp1 or Met1, respectively), in the case of Ab1-16t he main coordination involves the backbone carbonyl (Asp1) and two His residues (Scheme 1a nd Figure 4).…”