The Botswana health care system once more engaged in a historic challenge of addressing and mitigating yet another pandemic-COVID-19; just like it did a few years ago when it was confronted with the HIV and AIDS pandemic. Both these pandemics have devastated the nation in a very unprecedented manner. The country has learned how to respond to and address a pandemic situation.Although COVID-19 did not cause more deaths than HIV and AIDS, it was more devastating because it was erratic and unpredictable in how it spread. It is very frustrating because this virus is spread from one person to the other through various sources, and a person does not know where they could have contacted it. This, therefore, necessitated creative, swift, and radical approaches in decision-making to respond to this crisis (Lee et al., 2020). Healthcare leaders were also required to respond innovatively to make changes and decisions that were effective and prudent within a minimal time frame.