Coordination behavior and bio-potent aspects of Ni(II) with 2-aminobenzamide and some amino acid mixed ligands – Part II: Synthesis, spectral, morphological, pharmacological and DNA interaction studies

Dharmaraja, Jeyaprakash; Subbaraj, Paramasivam; Esakkidurai, Thirugnanasamy; Shobana, Sutha

doi:10.1016/j.saa.2014.04.184

Cited by 18 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The quantitative assays gave minimum inhibitory concentration values of the range of 25-100 µg/ml are confirmed that the results are superior to the previously published values [24,25]. Coordination complex about antimicrobial active C=O part of metal(II) ions decreases the polarity of metal ions significantly due to the partial sharing of its positive charge with donor groups and delocalization of pi electrons [26] over the whole chelate ring resulting in high degree of inhibition [27] is due to the more antimicrobial activity of the present sample.…”

Section: Kirby-bauer Agar Well Diffusion Assaysupporting

confidence: 62%

In Vitro Study of Antimicrobial and Antioxidant Activities of Oxalic Acid-Derived Bioactive Chelating Agent

F¹,

S²

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The aim of this study is to evaluate the biological potentials of sodium cadmium oxalate dihydrate complex prepared by a single diffusion method in the silica gel medium. Methods: The present complex was derived by the oxalic acid using a single diffusion method in gel medium and tested for single-crystal X-ray diffraction, ultraviolet-visible (UV) spectrum (190–500 mm), and solubility (distilled water at 20–29°C) studies. Antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl assay, and antimicrobial activity was measured by agar well diffusion method. Results: The present chelating complex was successfully synthesized by gel technique. The solubility of sodium cadmium oxalate dihydrate was moderately good for deionized warm water. The UV spectral studies confirmed the chelating O-H, Na-O, and C-O bonds of the newly synthesized complex for the optical and biological properties. Conclusions: The metal-oxygen and oxygen-hydrogen bonds of the present newly synthesized sample much improved its optical, antimicrobial, and antioxidant activities and find its applications in the field of pharmaceutical and biomedical applications.

show abstract

Section: Kirby-bauer Agar Well Diffusion Assaysupporting

confidence: 62%

In Vitro Study of Antimicrobial and Antioxidant Activities of Oxalic Acid-Derived Bioactive Chelating Agent

F¹,

S²

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Oligomers derived from anthranilamide, on the other hand, exhibit intrinsic dipole moments which make them suitable candidates to serve as bioinspired molecular electrostatic analogues of magnets also known as electrets [ 14 ]. A series of novel bioactive mixed ligand Cu(II) complexes [ 15 ] and Ni(II) complexes [ 16 ] have been prepared before from 2-aminobenzamide and some amino acids and then evaluated for biological properties. 2-Aminobenzamide and its derivatives are envisaged to exist in four tautomeric forms and two closed pharmacophore sites through the formation of six-membered intramolecular rings assisted by hydrogen bonding, which are considered to be responsible for decreasing both antibacterial (C=O δ− – δ+ HN) and antifungal activity (C-OH δ+ – δ− N=C) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the enormous pharmacological [ 11 , 12 , 13 , 15 , 16 , 17 ] and chemical [ 19 , 20 , 21 , 22 , 23 , 24 ] interest in the N -unsubstituted 2-aminobenzamides, to our knowledge, the presence of intramolecular hydrogen bonding in these compounds has been less demonstrated in the literature [ 25 , 26 , 27 , 28 ]. This prompted us to study the structural properties of the known 5-bromo/iodo- and 3,5-dihalogenated 2-aminobezamides by means of spectroscopic (NMR, UV-Vis, IR, Raman) methods and single X-ray crystallography in combination with density functional theory methods.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic, DFT, and XRD Studies of Hydrogen Bonds in N-Unsubstituted 2-Aminobenzamides

et al. 2017

View full text Add to dashboard Cite

The structures of the mono- and the dihalogenated N-unsubstituted 2-aminobenzamides were characterized by means of the spectroscopic (1H-NMR, UV-Vis, FT-IR, and FT-Raman) and X-ray crystallographic techniques complemented with a density functional theory (DFT) method. The hindered rotation of the C(O)–NH2 single bond resulted in non-equivalence of the amide protons and therefore two distinct resonances of different chemical shift values in the 1H-NMR spectra of these compounds were observed. 2-Amino-5-bromobenzamide (ABB) as a model confirmed the presence of strong intramolecular hydrogen bonds between oxygen and the amine hydrogen. However, intramolecular hydrogen bonding between the carbonyl oxygen and the amine protons was not observed in the solution phase due to a rapid exchange of these two protons with the solvent and fast rotation of the Ar–NH2 single bond. XRD also revealed the ability of the amide unit of these compounds to function as a hydrogen bond donor and acceptor simultaneously to form strong intermolecular hydrogen bonding between oxygen of one molecule and the NH moiety of the amine or amide group of the other molecule and between the amine nitrogen and the amide hydrogen of different molecules. DFT calculations using the B3LYP/6-311++G(d,p) basis set revealed that the conformer (A) with oxygen and 2-amine on the same side predominates possibly due to the formation of a six-membered intramolecular ring, which is assisted by hydrogen bonding as observed in the single crystal XRD structure.

show abstract

“…Compared with complex 1, the stretching vibration peak of the C=O bonds in complex 3 moves to high wavenumber, which can illustrate that both the oxygen atoms in biuret molecules and acetate anions are coordinated to the manganese ions in complex 3. The absorption peaks at 476 cm −1 in complexes 1 and 2 are originated to the stretching vibrations of the Ni−O bonds, and the absorption peaks at 459 cm −1 in complexes 3 and 4 are the characteristic peaks of the Mn−O bonds [13][14][15][16][17]. Figures 5 and 6 show the Raman spectra of the complexes obtained in the 400−4000 cm −1 range, and the frequencies data of the biuret and its complexes are listed in Table 3.…”

Section: Ir Spectroscopy Analysismentioning

confidence: 99%

Synthesis, Optical Characterization, and Thermal Decomposition of Complexes Based on Biuret Ligand

Wang

Chen

2016

International Journal of Optics

View full text Add to dashboard Cite

Four complexes were synthesized in methanol solution using nickel acetate or nickel chloride, manganese acetate, manganese chloride, and biuret as raw materials. The complexes were characterized by elemental analyses, UV, FTIR, Raman spectra, Xray powder diffraction, and thermogravimetric analysis. The compositions of the complexes were, and [Mn(bi) 2 Cl 2 ] (4) (bi = NH 2 CONHCONH 2 ), respectively. In the complexes, every metal ion was coordinated by oxygen atoms or chlorine ions and even both. The nickel and manganese ions were all hexacoordinated. The thermal decomposition processes of the complexes under air included the loss of water molecule, the pyrolysis of ligands, and the decomposition of inorganic salts, and the final residues were nickel oxide and manganese oxide, respectively.

show abstract

Coordination behavior and bio-potent aspects of Ni(II) with 2-aminobenzamide and some amino acid mixed ligands – Part II: Synthesis, spectral, morphological, pharmacological and DNA interaction studies

Cited by 18 publications

References 35 publications

In Vitro Study of Antimicrobial and Antioxidant Activities of Oxalic Acid-Derived Bioactive Chelating Agent

In Vitro Study of Antimicrobial and Antioxidant Activities of Oxalic Acid-Derived Bioactive Chelating Agent

Spectroscopic, DFT, and XRD Studies of Hydrogen Bonds in N-Unsubstituted 2-Aminobenzamides

Synthesis, Optical Characterization, and Thermal Decomposition of Complexes Based on Biuret Ligand

Contact Info

Product

Resources

About