Coordination bonded stimuli-responsive drug delivery system of chemical actives with metal in pharmaceutical applications

Kothawade, Sakshi; Shende, Pravin

doi:10.1016/j.ccr.2024.215851

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.215851

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Coordination bonded stimuli-responsive drug delivery system of chemical actives with metal in pharmaceutical applications

Sakshi Kothawade,

Pravin Shende

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2024

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Cited by 12 publications

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Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity

Han,

Li,

et al. 2024

Angewandte Chemie

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The chirality of metal‐organic cages holds enormous potential for novel applications in diverse fields, while it is relatively rare to employ such asymmetric units for the construction of noncentrosymmetric materials. Herein, by self‐assembling the 4,4',4''‐nitrilotribenzoic acid (H3NBA) with bis(cyclopentadienyl)‐zirconium dichloride (Cp2ZrCl2, Cp = η5‐C5H5) in different solvent conditions, we have obtained three hierarchical packing modes of metallo‐tetrahedra with distinct spatial symmetry groups (designated as Zr‐α, Zr‐β, and Zr‐γ). Among them, Zr‐α employs a simple cubic arrangement and is a common centrosymmetric superstructure, which consists of a pair of equimolar metallo‐tetrahedra enantiomers in its unit cell. While Zr‐β results in conglomerates with spontaneous resolution without using any resolving agents, giving rise to two enantiopure entities separately (Zr‐β‐P, Zr‐β‐M). More importantly, Zr‐γ breaks the inversion center of symmetry and crystallizes into a racemic yet non‐centrosymmetric superstructure with face‐centered cubic packing mode. Based on the non‐centrosymmetric nature, the hierarchical superstructure Zr‐γ displayed good second harmonic generation activities. This work presents a successful instance wherein the reaction solvent induces the modulation of intermolecular packing mode to afford non‐centrosymmetric solid materials, which can greatly promote the development of noncentrosymmetric solid (NCS) materials.

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Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity

Han,

Li,

et al. 2024

Angewandte Chemie

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Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity

Han,

Li,

et al. 2024

Angew Chem Int Ed

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Recent advances and perspectives of multifunctional nanogels in biomedical applications

Han,

Dai,

Chen

2024

MedComm – Biomaterials and Applications

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Nanogels (NGs) are considered as a kind of nanoscale hydrogels (<200 nm) endowing with the functions of both nanomaterials and hydrogels. In the last 20 years, NGs have garnered significant attention due to their versatility and adaptability. Herein, a comprehensive overview of the latest advancements and current research status of NGs is provided, with a particular focus on the synthesis strategies involving physical and chemical cross‐linking methods, as well as the advantages of NGs in drug loading and responsive release. Based on the diverse design strategies of NGs, four key biomedical applications, including inflammation therapy, regenerative medicine, bioimaging and tumor therapy are further summarized and discussed. Moreover, the existed inherent challenges facing NGs are proposed, while highlighting their potential to revolutionize therapeutic and diagnostic approaches. Finally, we look forward to the further development and promising potentials of NGs in biomedical applications. This review aims to serve as a valuable reference for researchers, providing some insights into the evolving landscape of NGs and their potential in advanced biomedical applications.

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Coordination bonded stimuli-responsive drug delivery system of chemical actives with metal in pharmaceutical applications

Cited by 12 publications

References 100 publications

Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity

Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity

Chiral Metal Self‐Assemblies of Zirconium‐Tetrahedra and Their Second Harmonic Generation Activity

Recent advances and perspectives of multifunctional nanogels in biomedical applications

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