Coordination chemistry of pyrazine derivatives analogues of PZA: design, synthesis, characterization and biological activity

Abstract

A novel Ru(iii) complexes were synthesized and characterized. Their stabilities were discussed in terms of aqueous and MeCN solutions. Antimicrobial properties of complexes studied were characterized against reference strains of bacteria and yeast.

When biomolecules meet 2-hydrazinopyrazine: from theory through experiment to molecular levels using a wide spectrum of techniques

“…This investigation was planned based on the knowledge acquired from the physicochemical properties of other pyrazine derivatives reported by us previously. 23,24,62 The initial step of the investigation included the preliminary determination of the relation between the HClO 4 molar concentration and the H o index. The obtained for 2HP results presented in Fig.…”

“…Some of these compounds including pyrazine-2aminoxime (PAOX), pyrazine-2-thiocarboxamide (PTCA), and 2-amine-5-bromo-3-(methylamine)pyrazine (ABMAP) were previously investigated by our group. [23][24][25] In the discovery of biologically active compounds, there are several important issues such as structure, tautomerism, acidbase equilibrium, hydrophobicity, and membrane permeability. Knowledge of these properties allows the potential biological and therapeutic activities and behavior of compounds in the body or environment to be predicted.…”

Cu(II) and Ni(II) Complexes with New Tridentate NNS Thiosemicarbazones: Synthesis, Characterisation, DNA Interaction, and Antibacterial Activity

“…The fight against infectious diseases, one aspect of this field, has seen great advances; however, antimicrobial resistance remains a major obstacle and continues to increase, and it is now considered a global public health problem [5]. Multiple investigations have been performed to test new free organic or metal coordination compounds, which can be precursors of more efficient and less toxic drugs by acting through different biological mechanisms [6–8].…”

Synthesis of Novel Sulfamethaoxazole 4-Thiazolidinone Hybrids and Their Biological Evaluation

“…This endopeptidase is part of a complex proteolytic MMP enzyme family, where its over expression has been linked to several pathological processes [ 48 ]. As several articles had already described the coordination of metals by sulfur containing compounds [ 49 , 50 ], we investigated whether the sulfamethaoxazole in our compounds could coordinate the Zn 2+ ion in MMP-8. This could promote potential inhibitory activity on MMP-8, as presented by Tauro et al [ 48 ].…”