Coordination chemistry of Schiff base tin complexes

Manju, .; Mishra, Neelima; Kumar, Dinesh

doi:10.1134/s1070328414050091

Cited by 20 publications

(2 citation statements)

References 108 publications

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“…Metal complexes are one of the most effective anticancer medications, which are created from synthetic or natural compounds. Some metal complexes have special features that boost their antitumor efficacy ( Evans, 1990 ; Delgado et al, 2010 ; Baghbanzadeh et al, 2011 ; Morschhäuser et al, 2012 ; Wang et al, 2013 ; Manju et al, 2014 ; Yan et al, 2015 ; Chundawat et al, 2021 ). Lots of high-quality research have been done on the interaction of various complexes with DNA and BSA.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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To learn more about the chemotherapeutic and pharmacokinetic properties of a neodymium complex containing 1,10-phenanthroline (dafone), In vitro binding was investigated with bovine serum albumin and fish-salmon DNA, using a variety of molecular modeling research and biophysical approaches. A variety of spectroscopic techniques including fluorescence and absorption were used to investigate the interplay between DNA/BSA and the neodymium complex. The findings revealed that the Nd complex had a high affinity for BSA and DNA interplays through van der Waals powers. In addition, the binding of the Nd complex to FS-DNA mainly in the groove binding mode clearly reflects with iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, and viscosity studies. It was observed that the Nd complex binds to FS-DNA through a minor groove with 3.81 × 105 (M−1). Also, Kb for BSA at 298 K was 5.19×105 (M−1), indicating a relatively high affinity of the Nd complex for DNA and BSA. In addition, a competitive study of a docking investigation revealed that the neodymium complex interacts at BSA site III. The results obtained from the binding calculations are well consistent with the experimental findings. Also, cytotoxicity studies of Nd complex were performed in MCF-7 and A-549 cell lines and the results show that this new complex has a selective inhibitory effect on the growth of various cancer cells.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Raeisi Vanani,

Asadpour,

Aramesh-Boroujeni

et al. 2023

Front. Chem.

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“…Based on structural variety, type, quantity, and arrangement of donor atoms linked to the tin metal, Schiff bases with biologically reactive donor atoms are in high demand due to their better solubility and simplicity of production [41,42]. The biological activity of unsymmetrical habitats of Schiff base ligands with continuous stoichiometry and varied methods of coordination is also facilitated by the Schiff bases, which continue to have a wide range of analytical and therapeutic applications [43,44]. The toxicity of alkylorganostannanes is highly dependent on the alkyl group, and the quantity of alkyl groups reduces activity as follows for Sn (IV) compounds, with no impact on the activity from anionic group [45]:…”

Section: Checking Biological Activitymentioning

confidence: 99%

Synthesis and Applications of Organotin(IV) Compounds: Mini Review

Naoom¹,

Yousif²,

Zainulabdeen³

et al. 2023

JSMPM

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Organotin(IV) compounds have seen a marked increase in industry utilization over the years and exhibited enormous economic benefits as well as environmental costs due to their numerous industrial, medical, and agricultural uses and other applications. The present review is a continuation of aseries of reviews on the use of organotin(IV), chemicals, synthesis, characteristics and geometry as well as the industrial and biological applications.

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Comprehensive Investigation of Organotin(IV) Complexes Derived From a Novel Schiff Base: Synthesis, Characterization, Antioxidant, ADME Profiling, and In Vitro Biological Evaluation

Abbas,

Zahid,

Parveen

et al. 2024

Applied Organom Chemis

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Six organotin(IV) complexes (1–6) were synthesized, following the general formulas as R2Sn(L)Cl and R3Sn(L), have been reported. In these complexes, L represents a Schiff base prepared by the reaction of phenylhydrazine with 5‐bromo‐2‐hydroxybenzaldehyde, and R = Me, n‐Bu, Ph. Various analytical techniques were employed to characterize and determine the structure of the newly synthesized compounds. The techniques, including the elemental analysis, molar conductivity measurements, UV–visible, FT‐IR, NMR spectroscopy, and mass spectrometry. Spectroscopic analysis suggested that the ligand (4‐bromo‐2‐[(2‐phenylhydrazinylidene)meth‐yl]phenol) (HL) coordinates with the tin (Sn) metal through its phenolic oxygen (O) and azomethine nitrogen (N) atoms. Molar conductivity measurements indicated that all the synthesized compounds are nonelectrolytes. The percent CHN analysis data also corroborates the spectroscopic results. UV–Vis spectra revealed the mode of transitions of electrons due to the π–π* transitions, n–π* transitions, and transitions involving charge transfer from the ligand to the metal, which occurred in recently developed ligand and organotin (IV) complexes. The emergence of additional bands in the FT‐IR spectra of complexes (1–6), attributed to ν(Sn–O) and ν(Sn–N), which were absent in the precursor, offers further proof for the synthesis of these complexes. NMR spectral studies give information about the nature and number of all protons having the same or different chemical environment in the structure of all the compounds being reported in this study. The potential to be used as bioactive compounds in the future was assessed by performing the biological activities (antimicrobial and antioxidant) of these synthesized compounds and the DPPH free radical method for the antioxidant potential of these compounds. Based on these assessments, it can be concluded that the ligand's efficiency improves upon complexation, primarily due to the type and quantity of alkyl groups attached to the [Sn] metal atom. ADME and studies were conducted to forecast the biological effectiveness of the ligand and its metal complexes. Among these, the ligand and complexes 1 and 4 are prioritized for docking with Aspergillus flavus, Bacillus subtilis, and Escherichia coli. The complexes 1 and 4 were found biologically more effective towards different microbes. The Antioxidant activity of the test complexes follows this trend: Methyltin(IV) complexes exhibit the lowest activity, whereas butyltin(IV) and phenyl(IV) complexes exhibit higher levels of activity, with phenyltin(IV) showing the most significant activity.

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Coordination chemistry of Schiff base tin complexes

Abstract: The most important results of extensive studies of tin metal complexes with Schiff base ligands are reviewed. A large number of inorganic compounds are known but still there is a need of new compounds to develop various efforts in different fields for biomedical applications.

Cited by 20 publications

References 108 publications

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

RETRACTED: Studying the interaction between the new neodymium (Nd) complex with the ligand of 1,10-phenanthroline with FS-DNA and BSA

Synthesis and Applications of Organotin(IV) Compounds: Mini Review

Comprehensive Investigation of Organotin(IV) Complexes Derived From a Novel Schiff Base: Synthesis, Characterization, Antioxidant, ADME Profiling, and In Vitro Biological Evaluation

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