Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances

Abstract

Four mononuclear complexes (H3O){[NiL3](ClO4)3} (1), [CoL3](ClO4)2·2H2O (2), [CdL2Cl2] (3) and [CuL3](NO3)2 (4) have been prepared employing a newly synthesized 1,2,4-triazole ligand: 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1H-1,2,4-triazole (L). The structures of the complexes, which crystallized in P63/m (1), P-1 (2), P1 (3), and P21/c (4), are reviewed within the context of the cooperative effect of the hydrogen bonding network and counter anions on the supramolecular formations. Moreover, within the framework of biological activity examination, these compounds showed favorable antibacterial performances compared to those of various species of bacteria, including both Gram-positive and Gram-negative strains. Significant antifungal inhibitory activity towards Fusarium oxysporum f. sp. albedinis fungi was recorded for 3 and 4 over the ligand L.

Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes

“…By comparing L 1 , C 1 and L 2 , C 2 , respectively, a shift in the bands is systematically observed, which points to metal coordination. Furthermore, the peak at 1058 cm −1 becomes stronger in C 1 compared to L 1 , which can be explained by the presence of non-coordinating perchlorate anions [ 32 ]. Using FT-IR, we were unable to observe bands corresponding to Cd-O, Cd-N, Ni-O, and Ni-N, which are theoretically expected below 500 cm −1 [ 33 , 34 , 35 ].…”

Molecular docking studies, structural analysis, biological studies, and synthesis of certain novel Schiff base from benzohydrazide derivate

“…For example, in a study by Draoui, Y et al a series of triazole-based Schiff bases were synthesized and evaluated for their antibacterial studies against Gramnegative and Gram-positive bacteria. Some of the compounds exhibited even better activity than standard antibiotics [15]. Overall, Schiff bases are versatile compounds with diverse applications in medicine, pharmacology, and materials science.…”

High Inhibition for a CoII Tetrazole Bi‐pyrazole Dinuclear Complex against Fusarium Oxysporum f. sp. Albedinis

“…Pyrazole-based precursors have raised great interest due to their use in a variety of fields with broad socio economic implications, such as pharmaceutics and biology, catalysis, corrosion inhibition, [1][2][3] and environmental studies. [4][5][6][7] The incorporation of a tetrazole ring to produce a pyrazole-tetrazole platform can lead to a variety of applications, based on medicinal chemistry, [8,9] catalysis, [10] energetic materials, [11,12] magnetism, [13] spin crossover, [14] chemical sensing, [15,16] luminescent properties, [17] to name but a few. On the other hand, metal complexes are gaining popularity as a promising alternative to traditional organic antibiotics.…”

“…[22] Up to now, a wide range of Cu II , Co II and Cd II complexes with azole based donor ligands have shown remarkable antifungal and antibacterial activities, [23][24][25] together with a low toxicity. [9] A vascular disease caused by the fungal infection of Fusarium oxysporum f. sp. is causing several damages to cash crops including banana, garlic, tomato and palm all over the world.…”

“…[26] As a solution, several specific compounds have been proposed to stimulate the plant defense system against pathogen attack, such as some heterocyclic ligands, [29,30] and coordination complexes. [9,31,32] It is still however challenging to develop efficient compounds capable of high inhibitory activity at low concentration.…”