Coordination Complexes of Manganese and Their Biomedical Applications

Ali, Basharat; Iqbal, Muhammad Adnan

doi:10.1002/slct.201601909

Cited by 48 publications

(22 citation statements)

References 134 publications

(208 reference statements)

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“…Intracellular ROS generation was probed by using non‐polar cell permeable 2’,7’‐dichlorofluorescein diacetate (DCFH‐DA) (Figure ). The dye is cleaved by intracellular esterases and subsequently oxidized by intracellular ROS or ROS generated in situ into highly green fluorescent 2′,7′‐dichlorofluorescein (DCF) –,. The fluorescence intensity is proportional to the concentration of intracellular ROS.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Theory and In Vitro Photodynamic Activities of New Copper(II)‐Histidinito Complexes

Musib¹,

Banerjee²,

Garai³

et al. 2018

ChemistrySelect

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The photo‐dynamic effect of four new copper(II)‐histidinito complexes with phenanthroline‐based ligands were studied in details. All the complexes were tested against HeLa (Human Cervical Carcinoma) and 3T3 (normal fibroblast) cells both in dark and in visible light. Although the complexes were toxic to HeLa cells (IC50 ∼ 10 μM), visible light (400‐700 nm) remarkably enhanced the cytotoxicity of the complexes to the extent of sub‐micromolar level. Several photo‐physical measurements along with the Time‐dependent density functional theory (TD‐DFT) calculations rationalize the level of photodynamic therapy (PDT) effect of the complexes, which is related to the generation of singlet oxygen (1O2) on photo‐activation. Presence of low lying, long‐lived triplet excited states facilitating the effective intersystem crossing was responsible for generation of higher level of singlet oxygen in pyrenyl complex. High level of reactive oxygen species (ROS) on photo‐activation is primarily responsible for apoptotic photo‐cytotoxicity. Fluorescence microscopy revealed the cytosolic localization of the complex.Overall results are of paramount importance towards designing of next generation metal‐based PDT agents as the viable alternatives of porphyrins.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Theory and In Vitro Photodynamic Activities of New Copper(II)‐Histidinito Complexes

Musib¹,

Banerjee²,

Garai³

et al. 2018

ChemistrySelect

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“…Manganese continues to play a prominent role in the chemistry of 3d transition metals, owing to its significance across a breadth of research areas, including bioinorganic [1] and biomedicinal chemistry [2], catalysis [3], nanomaterials [4], spectroscopy [5], and molecular magnetism [6]. In the latter category, the ability of the Mn ion to exist in a variety of stable oxidation states (II-IV) allows for the construction of polymetallic cluster compounds exhibiting a variety of interesting magnetic behaviours, including the stabilization of large spin ground states [7], the slow relaxation of magnetization [8], spin frustration [9], vibrational coherences [10], and enhanced magnetocaloric effects [11].…”

Section: Introductionmentioning

confidence: 99%

A Brucite-Like Mixed-Valent Cluster Capped by [MnIIIp-tBu-calix[4]arene]− Moieties

et al. 2020

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p-tBu-calix[4]arene (H4TBC[4]) has proven to be an incredibly versatile ligand for the synthesis of 3d- and 3d/4f- clusters, in particular those containing mixed-valent Mn ions. These are of interest to the magnetochemist for the diversity of magnetic behaviours that can be shown, along with a huge variety of nuclearities and topologies accessible, which allow one to outline magneto-structural correlations and a quantitative understanding of their properties. This contribution reports the synthesis, analysis and magnetic properties of a Brucite-like Mn-oxo/hydroxo octanuclear fragment encapsulated within/capped by four [MnIII-TBC[4]]− moieties. A diol coligand in the reaction mixture plays a seemingly important role in determining the outcome, though it is not incorporated in the final structure.

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“…Cancer has been a major concern in most of the research that has been published in the past decade under the umbrella of molecular biology, medicine and synthetic chemistry [1][2][3]. A wide range of novel compounds and their metallic complexes have been reported recently for their anticancer and proapoptotic potential [2,[4][5][6][7][8][9]. Although most of the candidates for future anti-cancer medications are synthetic in nature, the significance of the natural cytotoxic compounds cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Pro-Apoptotic Properties of Ethyl-p-Methoxycinnamate and Its Hydrophilic Derivative Potassium-p-Methoxycinnamate

et al. 2018

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Purpose The present study was designed to investigate the underlying mechanism of cytotoxic and pro-apoptotic potential of ethyl-p-methoxycinnamate (EPMC) and its hydrophilic derivative potassium-p-methoxycinnamate (KPMC). Methods EPMC was isolated from Kaempferia galanga extract and its ethyl chain was replaced with potassium by KOH reflux to synthesize KPMC. The anti-proliferative effect of EPMC and KPMC was evaluated in six cancer cell lines and two normal cell lines by MTT assay. The inhibitory effects of the test compounds on colony formation, cell migration, chromatin condensation and mitochondrial membrane potential was further investigated in HCT-116 cells whereas their effect on caspase 3, 7, 8 and 9 activities was studied in HCT-116 and PC-3 cells. Results EPMC exhibited significant antiproliferative effect in all six cancer cell lines with maximum cytotoxicity against HCT-116 cells (selectivity index > 6). Our results showed significant inhibition of cell migration and colony formation in EPMC-treated colorectal carcinoma cells (HCT-116) when compared to the normal colon fibroblasts (CCD-18co). It exhibited dose dependent chromatin condensation and loss of mitochondrial membrane potential with subsequent induction of caspase 3/7 activity. KPMC did not inhibit the proliferation of either cell lines in MTT assay. Moreover, the cell migration, colony formation and caspase induction in KPMC-treated cells was comparable with the negative control. Conclusion The replacement of alkyl chain in EPMC by potassium resulted into the loss of cytotoxic and pro-apoptotic effects of EPMC.

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Coordination Complexes of Manganese and Their Biomedical Applications

Cited by 48 publications

References 134 publications

Synthesis, Theory and In Vitro Photodynamic Activities of New Copper(II)‐Histidinito Complexes

Synthesis, Theory and In Vitro Photodynamic Activities of New Copper(II)‐Histidinito Complexes

A Brucite-Like Mixed-Valent Cluster Capped by [MnIIIp-tBu-calix[4]arene]− Moieties

Cytotoxic and Pro-Apoptotic Properties of Ethyl-p-Methoxycinnamate and Its Hydrophilic Derivative Potassium-p-Methoxycinnamate

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