Coordination of DNA Replication and Histone Synthesis During S Phase

Paik, Johanna; Giovinazzi, Serena; Gunjan, Akash

doi:10.1007/978-3-319-24696-3_11

Cited by 1 publication

(1 citation statement)

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“…Histone deposition is tightly regulated by specific chaperones [ 15 ], especially during the S-phase of cell division, where timely and coordinated assembly of newly synthesized DNA into chromatin preserves genome integrity and regulates gene expression [ 16 , 17 , 18 , 19 , 20 , 21 ]. Cell division significantly increases the histone pool within a specialized subnuclear compartment called the histone locus body (HLB) [ 18 , 22 ], which facilitates spatial assembly of transcription factors and mRNA processing components around histone loci to promote rapid expression and processing of canonical histone mRNAs [ 23 , 24 ].…”

Section: Canonical and Non-canonical Histonesmentioning

confidence: 99%

Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer

Dhahri,

Saintilnord,

Chandler

et al. 2024

IJMS

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The incorporation of histone variants has structural ramifications on nucleosome dynamics and stability. Due to their unique sequences, histone variants can alter histone–histone or histone–DNA interactions, impacting the folding of DNA around the histone octamer and the overall higher-order structure of chromatin fibers. These structural modifications alter chromatin compaction and accessibility of DNA by transcription factors and other regulatory proteins to influence gene regulatory processes such as DNA damage and repair, as well as transcriptional activation or repression. Histone variants can also generate a unique interactome composed of histone chaperones and chromatin remodeling complexes. Any of these perturbations can contribute to cellular plasticity and the progression of human diseases. Here, we focus on a frequently overlooked group of histone variants lying within the four human histone gene clusters and their contribution to breast cancer.

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