Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging

Irazoki, Andrea; Aparicio, Pilar; Aris, Cecilia; Alibakhshi, Esmaeil; Rubio-Valera, María; Castellanos, Juan; Lores, Luis; Palacı́n, Manuel; Gumà, Anna; Zorzano, António; Sebastián, David

doi:10.1111/acel.13583

Cited by 37 publications

(28 citation statements)

References 47 publications

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“…Interestingly, inflammation and mDAMPs synergistically contribute to sarcopenia [ 56 ]; for example, mDAMPs can activate the Toll-like receptor (TLR) pathway and trigger NF-κB signaling, thus increasing the expression of IL-6 and TNF-α [ 57 ]. Damaged mitochondria can activate the NLRP3 inflammasome, triggering the expression of the proteolytic cytokines IL-18 and IL-1β and enhancing inflammation, likely causing pyroptosis ( Figure 1 ) [ 58 ].…”

Section: Inflammation In Sarcopeniamentioning

confidence: 99%

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Jiménez-Gutiérrez

Martínez-Gómez

Martínez-Armenta

et al. 2022

Cells

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Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is also related to chronic diseases such as metabolic dysfunction associated with diabetes and obesity. This means that everyone will be vulnerable to sarcopenia at some point in their life. Research to find the precise molecular mechanisms implicated in this condition can increase knowledge for the better prevention, diagnosis, and treatment of sarcopenia. Our work gathered the most recent research regarding inflammation in sarcopenia and new therapeutic agents proposed to target its consequences in pyroptosis and cellular senescence. Finally, we compared dual X-ray absorptiometry (DXA), magnetic resonance imaging (MRI), and ultrasound (US) as imaging techniques to diagnose and follow up on sarcopenia, indicating their respective advantages and disadvantages. Our goal is for the scientific evidence presented here to help guide future research to understand the molecular mechanisms involved in sarcopenia, new treatment strategies, and their translation into clinical practice.

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Section: Inflammation In Sarcopeniamentioning

confidence: 99%

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Jiménez-Gutiérrez

Martínez-Gómez

Martínez-Armenta

et al. 2022

Cells

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“…These compounds demonstrate a strong ability to activate anabolic pathways and to counteract age/disease-related changes involved in muscle degeneration, such as mitochondrial alterations and inflammatory processes [132]. In particular, several studies point to the role of EVOO in maintaining mitochondrial homeostasis through modulation of Sirt1 and PGC1-α expression (Figure 4), and this data appears extremely interesting, especially in light of the fact that accumulation of dysfunctional mitochondria is a major contributing factor to the development of sarcopenia [133][134][135]. Therefore, examining more closely the efficacy of EVOO phenols and studying their mechanisms of action in skeletal muscle models of aging both in vivo and in vitro are essential for designing new therapeutic approaches with the aim of treating sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Extra Virgin Olive Oil (EVOO), a Mediterranean Diet Component, in the Management of Muscle Mass and Function Preservation

et al. 2022

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Aging results in a progressive decline in skeletal muscle mass, strength and function, a condition known as sarcopenia. This pathological condition is due to multifactorial processes including physical inactivity, inflammation, oxidative stress, hormonal changes, and nutritional intake. Physical therapy remains the standard approach to treat sarcopenia, although some interventions based on dietary supplementation are in clinical development. In this context, thanks to its known anti-inflammatory and antioxidative properties, there is great interest in using extra virgin olive oil (EVOO) supplementation to promote muscle mass and health in sarcopenic patients. To date, the molecular mechanisms responsible for the pathological changes associated with sarcopenia remain undefined; however, a complete understanding of the signaling pathways that regulate skeletal muscle protein synthesis and their behavior during sarcopenia appears vital for defining how EVOO might attenuate muscle wasting during aging. This review highlights the main molecular players that control skeletal muscle mass, with particular regard to sarcopenia, and discusses, based on the more recent findings, the potential of EVOO in delaying/preventing loss of muscle mass and function, with the aim of stimulating further research to assess dietary supplementation with EVOO as an approach to prevent or delay sarcopenia in aging individuals.

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“…Both sarcopenia and myosteatosis represent a loss of muscle function and quality. Inflammatory responses and oxidative stress are primary etiological factors in muscle wasting 39 . Inflammatory cytokines can disrupt the balance between muscle protein synthesis and degradation, leading to muscle wasting, 40 including chronic inflammation driven by interleukin‐1, interleukin‐6, and tumor necrosis factor‐alpha, which are associated with sarcopenia 41 .…”

Section: Discussionmentioning

confidence: 99%

Body composition is associated with postoperative complications in perihilar cholangiocarcinoma

Wang,

Mantas,

Heij

et al. 2024

Cancer Medicine

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BackgroundPerihilar cholangiocarcinoma (pCCA) is a malignant tumor of the hepatobiliary system which is still associated with a challenging prognosis. Postoperative complications play a crucial role in determining the overall prognosis of patients with pCCA. Changes in body composition (BC) have been shown to impact the prognosis of various types of tumors. Therefore, our study aimed to investigate the correlation between BC, postoperative complications and oncological outcome in patients with pCCA.MethodsAll patients with pCCA who underwent curative‐intent surgery for pCCA between 2010 and 2022 were included in this analysis. BC was assessed using preoperative computed tomography and analyzed with the assistance of a 3D Slicer software. Univariate and multivariate binary logistic regression analyses were conducted to examine the relationship between BC and clinical characteristics including various measurements of postoperative complications and Cox regressions and Kaplan–Meier analysis to evaluate oncological risk factors in the study cohort.ResultsBC was frequently altered in patients undergoing curative‐intent liver resection for pCCA (n = 204) with 52.5% of the patients showing obesity, 55.9% sarcopenia, 21.6% sarcopenic obesity, 48.5% myosteatosis, and 69.1% visceral obesity. In multivariate analysis, severe postoperative complications (Clavien‐Dindo ≥3b) were associated with body mass index (BMI) (Odds ratio (OR) = 2.001, p = 0.024), sarcopenia (OR = 2.145, p = 0.034), and myosteatosis (OR = 2.097, p = 0.017) as independent predictors. Furthermore, sarcopenia was associated with reduced overall survival (OS) in pCCA patients (sarcopenia vs. no‐sarcopenia, 21 months vs. 32 months, p = 0.048 log rank).ConclusionsBC is highly associated with severe postoperative complications in patients with pCCA and shows tendency to be associated impaired overall survival. Preoperative assessment of BC and interventions to improve BC might therefore be key to improve outcome in pCCA patients undergoing surgical therapy.

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Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 37 publications

References 47 publications

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Extra Virgin Olive Oil (EVOO), a Mediterranean Diet Component, in the Management of Muscle Mass and Function Preservation

Body composition is associated with postoperative complications in perihilar cholangiocarcinoma

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