Coordination of mitochondrial biogenesis by thyroid hormone

Weitzel, Joachim M.; Iwen, K. Alexander

doi:10.1016/j.mce.2011.05.009

Cited by 111 publications

(95 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thyroid hormones are major regulators of mitochondrial function and biogenesis [3]. In the mitochondrion, ATP production by the electron transport chain is driven by the electrochemical gradient across the inner mitochondrial membrane.…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid hormones regulate a number of cellular functions, a major one of which is regulation of mitochondrial energy production [2] and biogenesis [3], and we have previously described impaired thyroid hormone-regulated mitochondrial function in patients with subclinical hypothyroidism [4]. Therefore, we aimed to examine individual changes in TSH and thyroid hormones after hemithyroidectomy, focusing on tissue response to hemithyroidectomy-induced thyroid functional changes by examining the mitochondrial function of peripheral blood mononuclear cells (PBMCs) before and during the first year after hemithyroidectomy for benign euthyroid goiter.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Kristensen¹,

Larsen²,

Pedersen³

et al. 2014

Eur Thyroid J

View full text Add to dashboard Cite

Background: The significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after hemithyroidectomy is unknown. Our aim was to examine changes in TSH and thyroid hormones after hemithyroidectomy for benign euthyroid goiter, focusing on tissue response by examining the mitochondrial membrane potential (MMP) of peripheral blood mononuclear cells (PBMCs) and basal oxygen consumption (V˙O₂). Materials and Methods: In a prospective study on 28 patients and controls, we examined serum TSH and thyroid hormones before hemithyroidectomy and 1, 3, 6 and 12 months after hemithyroidectomy for benign euthyroid goiter. In the hemithyroidectomy group, flow cytometry was used to measure the MMP of tetramethylrhodamine methyl ester (TMRM)- and MitoTracker Green (MTG)-stained PBMCs, and V˙O₂ was measured by an Oxycon Pro apparatus. Results: One year after hemithyroidectomy, TSH had increased from a median of 0.97 mIU/l (interquartile range, IQR: 0.69-1.50 mIU/l) to 2.10 mIU/l (IQR: 1.90-3.00 mIU/l; p < 0.001); free thyroxine (fT₄) had decreased from a median of 16.0 pmol/l (IQR: 14.9-17.0 pmol/l) to 14.8 pmol/l (IQR: 14.1-16.4 pmol/l; p = 0.009), whereas total triiodothyronine variations did not differ from those in controls. Concomitantly, the MMP of TMRM- and MTG-stained PBMCs was increased by 58% (p < 0.001) and 22% (p = 0.008), respectively. V˙O₂ was increased by 14% (p = 0.01). Conclusion: Hemithyroidectomy for benign euthyroid goiter induced persistently increased TSH and decreased fT₄, sustained mitochondrial hyperpolarization and increased V˙O₂. Our results demonstrate a decrease after hemithyroidectomy of the metabolic state to which the individual is adapted, with persistent cellular metabolic changes in a hemithyroidectomized patient group which is normally considered clinically and biochemically euthyroid.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Kristensen¹,

Larsen²,

Pedersen³

et al. 2014

Eur Thyroid J

View full text Add to dashboard Cite

show abstract

“…The ability of thyroid hormone (T3 and T4) and thyroid hormone receptors (TRs) to regulate oxygen uptake and energy utilization is related to the thyroid system's multiple effects on mitochondrial function. TH targets several regulatory pathways for gene expression that may contribute to mitochondrial biogenesis (Weitzel and Iwen, 2011). TH binds to nuclear-localized TR belonging to a ligand-dependent transcription factor family that modulates nuclear gene expression via binding to a thyroid response or TRE motif.…”

Section: A Estrogens Erythropoietin and Thyroid Hormonementioning

confidence: 99%

Mitochondrial Quality Control as a Therapeutic Target

2015

View full text Add to dashboard Cite

“…Most informative are studies on different thyroid hormone receptor (THR) knockout mice together with isoform-selective agonists which suggest that thyroid hormone receptor-α (THRA) has dominant effects on thermogenesis, whereas thyroid hormone receptor-β (THRB) impacts on lipid metabolism [11,12,13,14,15]. The role of both isoforms of THR is further complicated by the fact that the unliganded THR may act as a repressor of TH signalling, which is reversed upon TH binding [16]. As this has major effects on the regulation of all components of the metabolic syndrome, we will review several recent landmark findings.…”

Section: Thyroid and Energy Regulation: Pathophysiological Consideratmentioning

confidence: 99%

Thyroid Hormones and the Metabolic Syndrome

2013

View full text Add to dashboard Cite

Background: Clustering of various metabolic parameters including abdominal obesity, hyperglycaemia, low high-density lipoprotein cholesterol, elevated triglycerides and hypertension have been used worldwide as metabolic syndrome to predict cardiometabolic risk. Thyroid dysfunction impacts on various levels of these components. Objectives: The purpose of the present review is to summarize available data on thyroid hormone-dependent action on components of the metabolic syndrome. Methods: A PubMed search for any combination of hyperthyroidism, thyrotoxicosis or hypothyroidism and metabolic syndrome, blood pressure, hypertension, hyperlipidaemia, cholesterol, high-density lipoprotein cholesterol, glucose, diabetes mellitus, body weight or visceral fat was performed. We included papers and reviews published between 2000 and today but accepted also frequently cited papers before 2000. Results: There is convincing evidence for a major impact of thyroid function on all components of the metabolic syndrome, reflecting profound alterations of energy homeostasis at many levels. Conclusion: Even though the interactions shown in animal models and man are complex, it is evident that insulin sensitivity is highest and adverse thyroid effects on the metabolic system are lowest in euthyroid conditions.

show abstract

Coordination of mitochondrial biogenesis by thyroid hormone

Cited by 111 publications

References 67 publications

Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Mitochondrial Quality Control as a Therapeutic Target

Thyroid Hormones and the Metabolic Syndrome

Contact Info

Product

Resources

About