Coordination of Mucosal Immunity by Innate Lymphoid Cells

Zhou, Jordan; Sonnenberg, Gregory F.

doi:10.1007/978-981-16-8387-9_8

Cited by 3 publications

(2 citation statements)

References 182 publications

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“…These seminal studies advanced the understanding of host immune defence at mucosal sites viz. respiratory, urogenital and gastrointestinal mucosae 5,8–12 as well as macromolecular absorption in the gastrointestinal tract 13–18 …”

Section: Introductionmentioning

confidence: 99%

“…6,7 These seminal studies advanced the understanding of host immune defence at mucosal sites viz. respiratory, urogenital and gastrointestinal mucosae 5,[8][9][10][11][12] as well as macromolecular absorption in the gastrointestinal tract. [13][14][15][16][17][18] Local sIgA, as well as systemic IgG and IgM, have been studied extensively and their importance in defence against infections at respiratory, gastrointestinal and urogenital tracts has been widely reported, [19][20][21] including the development of mucosal vaccines.…”

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confidence: 99%

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Intracellular immunoglobulin A (icIgA) in protective immunity and vaccines

2023

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Virus neutralization at respiratory mucosal surfaces is important in the prevention of infection. Mucosal immunity is mediated mainly by extracellular secretory immunoglobulin A (sIgA) and its role has been well studied. However, the protective role of intracellular specific IgA (icIgA) is less well defined. Initially, in vitro studies using epithelial cell lines with surface expressed polymeric immunoglobulin receptor (pIgR) in transwell culture chambers have shown that icIgA can neutralize influenza, parainfluenza, HIV, rotavirus and measles viruses. This effect appears to involve an interaction between polymeric immunoglobulin A (pIgA) and viral particles within an intracellular compartment, since IgA is transported across the polarized cell. Co‐localization of specific icIgA with influenza virus in patients' (virus culture positive) respiratory epithelial cells using well‐characterized antisera was initially reported in 2018. This review provides a summary of in vitro studies with icIgA on colocalization and neutralization of the above five viruses. Two other highly significant respiratory infectious agents with severe global impacts viz. SARS‐2 virus (CoViD pandemic) and the intracellular bacterium—Mycobacterium tuberculosis—are discussed. Further studies will provide more detailed understanding of the mechanisms and kinetics of icIgA neutralization in relation to viral entry and early replication steps with a specific focus on mucosal infections. This will inform the design of more effective vaccines against infectious agents transmitted via the mucosal route.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Intracellular immunoglobulin A (icIgA) in protective immunity and vaccines

2023

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Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota

Yoo,

2023

Exp Mol Med

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The mammalian gut is the most densely colonized organ by microbial species, which are in constant contact with the host throughout life. Hosts have developed multifaceted cellular and molecular mechanisms to distinguish and respond to benign and pathogenic bacteria. In addition to relatively well-characterized innate and adaptive immune cells, a growing body of evidence shows additional important players in gut mucosal immunity. Among them, unconventional immune cells, including innate lymphoid cells (ILCs) and unconventional T cells, are essential for maintaining homeostasis. These cells rapidly respond to bacterial signals and bridge the innate immunity and adaptive immunity in the mucosal barrier. Here, we focus on the types and roles of these immune cells in physiological and pathological conditions as prominent mechanisms by which the host immune system communicates with the gut microbiota in health and diseases.

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Regulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease

Xia,

Huang,

et al. 2024

Cell Commun Signal

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Tissue-resident memory T (TRM) cells are populations which settle down in non-lymphoid tissues instead of returning to secondary lymph organs after the antigen presentation. These cells can provide rapid on-site immune protection as well as long-term tissue damage. It is reported that TRM cells from small intestine and colon exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional and functional heterogeneity. In this review, we focus on the reason why they lodge in intestinal tract, their developmental plasticity of going back to to circulation, as well as their regulators associated with retention, maintenance, exhaustion and metabolism. We also elaborate their role in the inflammatory bowel disease (IBD) and discuss the potential therapeutic strategies targeting TRM cells. Graphical Abstract

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Coordination of Mucosal Immunity by Innate Lymphoid Cells

Cited by 3 publications

References 182 publications

Intracellular immunoglobulin A (icIgA) in protective immunity and vaccines

Intracellular immunoglobulin A (icIgA) in protective immunity and vaccines

Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota

Regulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease

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