Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis

Tang, You Chi; Ponsin, Khoren; Graham-Paquin, Adda-Lee; Luthold, Carole; Homsy, Kevin; Schindler, Magdalena; Tran, Viviane; Côté, Jean‐François; Bordeleau, François; Khadra, Anmar; Bouchard, Maxime

doi:10.1016/j.celrep.2023.112202

Cited by 1 publication

(1 citation statement)

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“…and MHC heterozygotes might have been negatively selected on the second MHC II allele present in the thymus. However, efferocytosis of dead cells or their debris could also allow the transfer of MHC-derived peptides from cells, including TECs, derived from one set of parents to cells from the other set of parents ( 40 ), thus adding a layer of complexity to the analysis of tetra. mice.…”

Section: Resultsmentioning

confidence: 99%

MHC heterozygosity limits T cell receptor variability in CD4 T cells

Brown,

White,

Shaw

et al. 2024

Sci. Immunol.

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αβ T cell receptor (TCR) V(D)J genes code for billions of TCR combinations. However, only some appear on peripheral T cells in any individual because, to mature, thymocytes must react with low affinity but not high affinity with thymus expressed major histocompatibility (MHC)/peptides. MHC proteins are very polymorphic. Different alleles bind different peptides. Therefore, any individual might express many different MHC alleles to ensure that some peptides from an invader are bound to MHC and activate T cells. However, most individuals express limited numbers of MHC alleles. To explore this, we compared the TCR repertoires of naïve CD4 T cells in mice expressing one or two MHC alleles. Unexpectedly, the TCRs in heterozygotes were less diverse that those in the sum of their MHC homozygous relatives. Our results suggest that thymus negative selection cancels out the advantages of increased thymic positive selection in the MHC heterozygotes.

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Section: Resultsmentioning

confidence: 99%