Coordination properties of the bioligands creatinine and creatine in various reaction media

New Disposable Electrochemical Paper‐based Microfluidic Device with Multiplexed Electrodes for Biomarkers Determination in Urine Sample

“…The recorded UV‐Vis spectra are shown in Figure S4. Thereby, an increase in absorbance intensity was observed in relation to the increase in creatinine concentration at a wavelength of 333 nm and a shoulder appear at wavelength range from 450 to 535 nm suggesting thus a complex formation as described elsewhere . The presence of several donor groups in the tautomeric form of creatinine determines its strong ability to form complexes with several metals, such as copper, platinum, and zinc , and in this case, the formation of a yellow complex between the Fe 3+ ion and creatinine is evident.…”

“…After complexation of the Fe 3+ ions at constant concentration and in excess, the intensity of the cathodic peak current of the non‐complexed ions decreased proportionally to the increase in the added creatinine concentration. This operating principle is based on monitoring of the reduction process of Fe 3+ /Fe 2+ for indirect creatinine determination as described in our previously work . The selected electroanalytical tool in this case was differential pulse voltammetry (DPV).…”

Ternary copper(II) complexes with N-carboxymethyl-l-prolinato(2−) ion and imidazole or creatinine: A comparative study of the interligand interactions influencing the molecular recognition and stability

“…Moreover, in recent years an additional effort is carried out in order to deepen on the influence of intra-molecular interligand interactions in the stability of the ternary and related complex species. Among all these bioligands, a limited attention has been paid to creatinine (2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, hereafter crea) which coordination properties were broadly reviewed by Mitewa [5] in a rather comprehensive report, some years ago. Since then, some new contributions have been made on the metal binding properties of crea because its relevant versatility as ligand, which can act in various tautomeric forms (Scheme 1), and due to its important roles in the kidney clearance as a relevant final product for the catabolism of the nitrogen biomolecules.…”

Cyclocreatine, an anticancer and neuroprotective agent. Spectroscopic, structural and theoretical study

“…Moreover, CyCre could be a suitable ligand for the development of coordination compounds because of its potential ability to coordinate several metal ions of biological and pharmacological interest through its N and O donor atoms, in analogy with creatine and creatinine [8,9]. It is also well known that the biological activities of coordination compounds are not only attributed to the properties of the metal center or of the organic ligand themselves, but also to the physicochemical, structural and electronic changes that arise due to the coordination.…”