Coordinatively unsaturated excited states and DNA-binding interactions

Photoprocesses of Copper Complexes That Bind to DNA

“…In line with an observation by Barton and co-workers, Meadows et al investigated the interaction between Cu(dmpp) 2 + and DNA in solution 57a…”

“…Figure shows that there was an interaction and that the adduct exhibited CT emission. However, the signal was definitely weaker than the one obtained from the bcp complex 57b. The adduct also exhibited a weak CD signal in the visible region.…”

Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(ii) polypyridyl complex

“…52,53 McMillin and coworkers have reported the interaction of Cu(BC) 2 + with DNA and described a nonclassical mode of binding involving bridging structures that lead to DNA aggregation and elongation without intercalation. [54][55][56] However, we recently tested the cytotoxic effect of [Cu(BC) 2 ] + in the dark, and the IC 50 values obtained (21.8 and 25.5 mM in A549 and A375 cells, respectively) reected moderate to low toxicity compared to cuprous neocuproine complex (IC 50 of 0.9 and 1.8 mM on A549 and A375 cells, respectively). These results indicated that, unlike neocuproine, the activity of BC is not considerably enhanced by the presence of copper.…”

A Bifunctional Platinum(II) Complex Capable of Intercalation and Hydrogen‐Bonding Interactions with DNA: Binding Studies and Cytotoxicity

“…[Pt(CNN)(L)] + (L = neutral ligand) complexes have been reported to display photoluminescence that is sensitive to the local microenvironment, [21,22] and they are structurally related to the wellknown intercalator [Pt(terpy)Cl] + . [23] Here we describe studies on DNA binding and cytotoxicity of the cyclometalated platinum(ii) complex [Pt(CNN)(4-dpt)]PF 6 (1) containing a pyridyl ligand that carries a triple hydrogen-bonding motif.…”