COPD and Incident Cardiovascular Disease Hospitalizations and Mortality: Kaiser Permanente Medical Care Program

Sidney, Stephen; Sorel, Michael; Quesenberry, Charles P.; deLuise, Cynthia; Lanes, Stephan; Eisner, Mark D.

doi:10.1378/chest.128.4.2068

Cited by 466 publications

(389 citation statements)

References 18 publications

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“…The moderate increase of total stroke risk in COPD found in this study is consistent with previous findings, [18,17,10] although some studies have suggested both…”

Section: Discussionsupporting

confidence: 93%

“…hypertension, smoking and diabetes. [10][11][12] However, even after adjustment for a wide range of confounders, and in analyses of nonsmokers, reduced lung function (low FEV1 and/or FVC) has been associated with increased risk of cardiovascular disease, [13] including all-cause stroke, [14] IS [15] and SAH, [9] respectively. The underlying reason is unclear, but mechanisms such as extracellular matrix degradation, inflammation and oxidative stress, have been suggested to contribute to both reduced lung function and development of stroke.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies reported a moderate (10-50%) risk increase. [16,10,17,18] However, results have been inconsistent. Feary et al [19] found an almost three-fold increase in stroke incidence, although this high effect was mainly observed in younger age groups, whereas other studies reported no significant association between COPD and stroke after adjustment for comorbidities.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

et al. 2015

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Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease.Söderholm, Martin; Inghammar, Malin; Hedblad, Bo; Egesten, Arne; Engström, Gunnar Link to publication Citation for published version (APA): Söderholm, M., Inghammar, M., Hedblad, B., Egesten, A., & Engström, G. (2016). Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease. European Journal of Epidemiology, 31(2), 159-168. DOI: 10.1007/s10654-015-0113-7 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. ABSTRACT BackgroundIt is uncertain whether the incidence of stroke is increased in patients with chronic obstructive pulmonary disease (COPD), and whether COPD is associated with all subtypes of stroke (i.e. ischemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage). We evaluated the association between COPD and incidence of stroke in a nation-wide cohort study. MethodsAll individuals between 40 and 84 years of age, hospitalised for COPD between 1987and 2003 in Sweden were identified in the Swedish hospital discharge register. For each COPD patient (n=103,419), one reference individual was randomly selected from the general population matched for year of birth, sex and county of residence.After excluding subjects with prior stroke, incidence rates during 10 years follow-up were calculated. Hazard ratios (HR) for stroke comparing COPD patients with reference subjects were estimated using Cox regression adjusting for demographics and comorbidities. ResultsIncidence of all-cause stroke (n events=17,402) was significantly increased in COPD patients compared to reference individuals ConclusionsIncidences of all stroke subtypes are increased in COPD, especially during the first years after COPD diagnosis. The association was independent of several comorbidities, although residual confounding from smoking and hypertension cannot be excluded. A global evaluation of stroke risk factors seems warranted in patients with COPD.

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“…The moderate increase of total stroke risk in COPD found in this study is consistent with previous findings, [18,17,10] although some studies have suggested both…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

et al. 2015

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“…(19,20,21) The Lung Health Study showed that a substantial proportion of deaths in patients with mild COPD was the result of cardiovascular complications, and a recent large epidemiologic study revealed increased cardiovascular mortality, particularly in patients younger than 65 years with COPD. (22,23) Because cardiac abnormalities clearly contribute to the overall morbidity associated with COPD, an understanding of their role and potential for treatment is vital.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Left and Right Ventricular Functions by Myocardial Performance Index in Patients with Chronic Pulmonary Disease.

Najeebsaeed¹

2016

IOSR

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Background:Development of right ventricular hypertrophy and eventual right side heart failure is common in patients with chronic obstructive pulmonary disease (COPD). However, some disturbance in left ventricular (LV) function has been observed among such patients. The co-existence between chronic obstructive pulmonary disease (COPD) and heart failure has been previously described. However, the co-existence between COPD and subclinical LV dysfunction, without the presence of heart failure symptoms, is less well understood. P=0.128), and RVMPI (Beta =1.436, p=0. 3(98.87 ± 8.41ms) 009). LV diastolic function parameters (A, E/A, and deceleration time of E) were impaired for groups 2 and 3 compared with group 1.Mitral early diastolic and late diastolic annular velocities ratio (Em/Am), were significantly lowest in COPD patients with PH(0.77±0.066), and the isovolumetric relaxation time (IVRT) was significantly longer in group 3(105.43±4.21ms) and group 2(102.27±4.45ms) in relation to control group(71.2±5.51ms). RV diastolic function, E/A ratio was higher in the control subjects compared with the patient groups. The tricuspid inflow velocities ratio (E/A) was significantly lowest value in COPD p=atients with PH (0.84 ± 0.04) and the isovolumetric relaxation time (IVRT) was significantly longer in group

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“…Las principales comorbilidades asociadas a la EPOC son la hipertensión arterial, diabetes mellitus, enfermedad arterial coronaria, insuficiencia cardiaca, infecciones respiratorias, cáncer y enfermedad arterial periférica (249), estando presentes todas en nuestros resultados. Es importante destacar que la prevalencia de las mismas varía ampliamente en los distintos estudios que han tratado el tema (250)(251)(252)(253). Y donde las comorbilidades se presentan como un factor de empeoramiento de pronóstico de los pacientes en todos los estudios.…”

Section: Discusión Del Análisis De Las Características De La Poblacióunclassified

La educación terapéutica en los pacientes con EPOC

Ayora¹

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La educación terapéutica en los pacientes con EPOCTESIS AgradecimientosPor fin ha llegado el momento. Después de tantos meses en los que había que saltar las barreras que se iban sumando para la realización del proyecto, las mismas , barreras me han hecho conocer personas que lo han hecho posible. Así que es difícil empezar los agradecimientos de esta tesis, ya que son muchas las personas que tiene un trocito de cada una de las páginas que la componen.Voy a empezar agradecer en las primeras personas que confiaron en mí para llevarla a cabo, Isabel y Loreto. Intentando motivarme cuando la captación no era buena y orientándome con sus conocimientos en cada uno de los apartados. Así que solo puedo decir gracias.A mis compañeros de la UJI por compartir y escuchar en mis momentos de agobio y desesperación. Pero sin duda a mi compañera, Vicky, que sin conocerme decido ayudarme en todo lo necesario, por qué sin ti esto no hubiera sido posible, he podido dejar pocos o muchos conocimientos a la ciencia pero sin duda, me llevo una amiga, gracias Vicky.Como no, a todos los pacientes que han, confiado en mí, pensando que yo les estaba aportando mucho, pero eran ellos los que me han enseñado todo lo que se de esta enfermedad. Así que siempre os estaré agradecida.Y a otros que aunque no se vean de forma física han aportado grandes granitos como mi novio y compañero de viaje en el camino de la vida, Carlos, por estar ahí cuando te he necesitado y siempre me has sabido comprender, muchas gracias, por ser tan bueno conmigo.A todos mis amigos, en especial a Raquel e Idoya, que aunque los he dejado un poco de lado los últimos meses siempre han estado motivando, como lo prometido es deuda por fin podré irme al viaje que me regalasteis para mi cumpleaños. A mis padres y hermana, solo me queda decirlos que prometo estar más tiempo con vosotros, ya no me volverá a quedar la excusa de que tengo que hacer tesis, a ti Belén prometo visitarte en Barcelona que hace un año que te fuiste y no he ido ni a ver tu casa, perdón.Y a tantas personas que no recuerdo en este momento pero sin duda tienen mucho que ver con estas páginas. Ana Folch Ayora RESUMENIntroducción: la EPOC es prevenible y tratable. En el curso de la misma aparecen uno o dos periodos de agudizaciones o exacerbaciones anuales, suponiendo un elevado coste sanitario. Por lo tanto la prevención de las exacerbaciones es un objetivo prioritario recogido en las principales guías de consenso. La educación terapéutica (ET) forma parte del tratamiento en la prevención secundaria y terciaria.Objetivo: Determinar y evaluar la efectividad de un programa estructurado de ET, en comparación con la atención tradicional, trascurridos tres meses del alta, en base al uso de recursos sanitarios utilizados, calidad de vida, conocimiento de la enfermedad y la adherencia al tratamiento.Material y métodos: revisión integradora de los ensayos clínicos que apliquen programas de ET, estudio descriptivo de la población EPOC en el Hospital Universitario General de las historias clínicas de los últimos 5 a...

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COPD and Incident Cardiovascular Disease Hospitalizations and Mortality: Kaiser Permanente Medical Care Program

Cited by 466 publications

References 18 publications

Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

Incidence of stroke and stroke subtypes in chronic obstructive pulmonary disease

Assessment of Left and Right Ventricular Functions by Myocardial Performance Index in Patients with Chronic Pulmonary Disease.

La educación terapéutica en los pacientes con EPOC

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