COPD assessment test and severity of airflow limitation in patients with asthma, COPD, and asthma&amp;ndash;COPD overlap syndrome

Kurashima, Kazuyoshi; Takaku, Yotaro; Ohta, Chie; Takayanagi, Noboru; Yanagisawa, Tsutomu; Sugita, Yutaka

doi:10.2147/copd.s97343

Cited by 36 publications

(29 citation statements)

References 21 publications

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“…ACO was considered as one of the phenotypes of COPD. Our study showed that ACO was independently associated with the total CCQ and symptom and functional domain scores, which was consistent with findings of other studies, in which subjects with ACO suffered from higher symptom burden than those with COPD alone [41][42][43].…”

Section: Discussionsupporting

confidence: 93%

Determinants of Clinical COPD Questionnaire in Patients with COPD: A Cross-Sectional Observational Study

Zhou¹,

Zhou²,

Peng³

et al. 2020

Respiration

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Background: The Clinical COPD Questionnaire (CCQ) has been suggested by the Global Initiative of Chronic Obstructive Lung Disease (GOLD) as a comprehensive symptom measurement tool, which helps to classify patients in order to direct pharmacological treatment. Therefore, it is essential to understand its determinants. Objectives: To identify the determinants of the overall CCQ score and scores of its 3 subdomains among chronic obstructive pulmonary disease (COPD) patients from China. Methods: A total of 1,241 COPD patients in the outpatient department of the Second Xiangya Hospital in China were recruited. Basic information and clinical data were collected. Differences in the GOLD categories based on Modified Medical Research Council Dyspnea Scale (mMRC), COPD Assessment Test (CAT), and CCQ were compared. Multiple linear regression analyses were performed to evaluate determinant factors of the total CCQ and subdomain scores. Results: The total CCQ and/or separate domain scores significantly differed with sex, age, BMI, smoking status, biomass fuel exposure, exacerbation frequency, mMRC, CAT, and GOLD grades and groups. Subjects with asthma-COPD overlap (ACO) had worse health status based on CCQ than those with COPD alone. As for the 16 subgroups based on GOLD 2017, statistical differences in the total CCQ and functional domain scores were found among subgroups 1A-4A, 1B-4B, and 1D-4D. The mMRC classified much more patients into more symptom groups than CAT and CCQ. No significant difference was observed in the GOLD categories between the CAT and CCQ (cut point = 1.5). Multiple linear regression analysis showed that smoking status, underweight, ACO, post-bronchodilator FEV1% predicted < 50%, exacerbation history, and mMRC were independently associated with the total CCQ score. Only 3 variables were significantly associated with the symptom domain: ACO, exacerbations, and mMRC; for the functional domain, age ≥75 years, ACO, post-bronchodilator FEV1% predicted < 50%, exacerbation history, and mMRC were significant; female sex, underweight, frequent exacerbations (≥2), and mMRC were significantly associated with higher scores in the mental do

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Section: Discussionsupporting

confidence: 93%

Determinants of Clinical COPD Questionnaire in Patients with COPD: A Cross-Sectional Observational Study

Zhou¹,

Zhou²,

Peng³

et al. 2020

Respiration

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“…However, asthma control was assessed according to the GINA 2010 report [29]; thus, impaired lung function might partially explain the poor control of asthma in the present study. Previously, it has been suggested that ACOS patients might have higher CAT scores than patients with asthma [39]. Therefore, we evaluated whether ACOS can be distinguished from asthma, using questionnaires that have been validated for clinical use.…”

Section: Discussionmentioning

confidence: 99%

Differences between asthma–COPD overlap syndrome and adult-onset asthma

et al. 2017

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Differences between asthma-COPD overlap syndrome (ACOS) and adult-onset asthma are poorly understood. This study aimed to evaluate these differences in a clinical cohort of patients with adult-onset asthma, as a part of the Seinäjoki Adult Asthma Study (SAAS).188 patients were diagnosed with adult-onset asthma and re-evaluated 12 years after diagnosis. They were divided into three groups based on smoking history and post bronchodilator spirometry values: 1) never- and ex-smokers with <10 smoked pack-years; 2) non-obstructive (forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) ≥0.7) patients with ≥10 pack-years; and 3) ACOS patients with ≥10 pack-years and FEV/FVC <0.7.ACOS patients had lower diffusing capacity (/V 86% predicted 98 or 96% predicted; p<0.001), higher blood neutrophil levels (4.50 3.60 or 3.85×10 L; p=0.008), and higher IL-6 levels (2.88 1.52 or 2.10 pg·mL, p<0.001) as compared to never- and ex-smokers with <10 pack-years, or non-obstructive patients with ≥10 pack-years smoking history, respectively. ACOS patients also showed reduced lung function, higher remaining bronchial reversibility and a higher number of comorbidities.This study shows distinct differences in diffusing capacity, blood neutrophil and IL-6 levels, bronchial reversibility, lung function and comorbidities between ACOS and adult-onset asthma. The present findings should be considered in the comprehensive assessment of adult asthma patients.

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“…However, there is evidence that the CAT score is also a useful tool in asthma [34][35][36], while asthma control test (ACT) is disease-specific and focuses on asthma control only.…”

Section: Limitationsmentioning

confidence: 99%