COPD education and cognitive behavioral therapy group treatment for clinically significant symptoms of depression and anxiety in COPD patients: a randomized controlled trial

Kunik, Mark E.; Veazey, Connie; Cully, Jeffery A.; Souchek, Julianne; Graham, David P.; Hopko, Derek R.; Carter, R.; Sharafkhaneh, Amir; Goepfert, Eric; Wray, Naomi R.; Stanley, Melinda A.

doi:10.1017/s0033291707001687

Cited by 182 publications

(172 citation statements)

References 58 publications

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“…In line with these findings, a recent meta-analysis revealed only small, nonsignificant effects of CBT on self-reported symptoms of depression in COPD patients [63]. In comparison to COPD education, CBT has been shown to have a comparable antidepressant effect [64].…”

Section: Effects Of Psychotherapymentioning

confidence: 83%

Depression and suicidality in COPD: understandable reaction or independent disorders?

Hegerl

Mergl

2014

Eur Respir J

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Both depression and chronic obstructive pulmonary disease (COPD) are prevalent, severe and often comorbid disorders. There is a risk of undertreatment for depression in patients with COPD as depressive symptoms, including suicidal tendencies, can erroneously be conceptualised as an understandable reaction to COPD and not as signs of an independent depressive disorder. In this context, the comorbidity rates of COPD and depression, the risk of suicidal behaviour in patients with COPD, and the evidence base for pharmaco-and psychotherapy in these patients are reviewed.Because symptoms of depression and COPD overlap it remains unclear how far the prevalence of major depression in COPD exceeds that in the general population. The suicide risk appears to be increased in COPD. Methodological studies providing evidence for the antidepressant efficacy of antidepressants or psychotherapy in patients with COPD are lacking. Recommendations for clinicians on how to separate depression from an understandable reaction to COPD are provided.Given the profound effects of depression on quality of life, life expectancy, COPD prognosis and suicide risk it is important to carefully diagnose and treat depression in patients with COPD according to national guidelines. @ERSpublications Comorbid depression has profound effects on COPD prognosis and should not be seen as understandable reaction to COPD

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Section: Effects Of Psychotherapymentioning

confidence: 83%

Depression and suicidality in COPD: understandable reaction or independent disorders?

Hegerl

Mergl

2014

Eur Respir J

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“…31 Simon and colleagues observed that persons who started antidepressant treatment in primary care experienced significant improvement in depression as well as function and disability. 32 The reduction in disability following depression treatment was as great in those with multimorbidity as in those without medical conditions. Although antidepressants are effective for treating depression in patients with a wide range of physical diseases, antidepressants do not reliably affect disease self-management behaviors in chronically ill patients, 31 which suggests the potential benefits of educational and psychosocial treatments.…”

Section: Discussionmentioning

confidence: 99%

Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk

et al. 2015

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“…Psychotherapy added to pulmonary rehabilitation significantly reduces depression in COPD patients [137]. Cognitive behavioural therapy also improves the quality of life in COPD patients with depression [138]. Finally, if depression is caused by systemic inflammation then treating lung inflammation or systemic anti-inflammatory treatments should also be effective and depression needs to be measured in controlled trials in COPD patients once these drugs are in large clinical trials.…”

Section: Treatmentmentioning

confidence: 99%

Systemic manifestations and comorbidities of COPD

Barnes¹,

Celli²

2009

Eur Respir J

1,476

1,113

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Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a complex disease involving more than airflow obstruction. Airflow obstruction has profound effects on cardiac function and gas exchange with systemic consequences. In addition, as COPD results from inflammation and/or alterations in repair mechanisms, the ''spill-over'' of inflammatory mediators into the circulation may result in important systemic manifestations of the disease, such as skeletal muscle wasting and cachexia. Systemic inflammation may also initiate or worsen comorbid diseases, such as ischaemic heart disease, heart failure, osteoporosis, normocytic anaemia, lung cancer, depression and diabetes. Comorbid diseases potentiate the morbidity of COPD, leading to increased hospitalisations, mortality and healthcare costs. Comorbidities complicate the management of COPD and need to be evaluated carefully. Current therapies for comorbid diseases, such as statins and peroxisome proliferator-activated receptor-agonists, may provide unexpected benefits for COPD patients. Treatment of COPD inflammation may concomitantly treat systemic inflammation and associated comorbidities. However, new broad-spectrum anti-inflammatory treatments, such as phosphodiesterase 4 inhibitors, have significant side-effects so it may be necessary to develop inhaled drugs in the future. Another approach is the reversal of corticosteroid resistance, for example with effective antioxidants. More research is needed on COPD comorbidities and their treatment.

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COPD education and cognitive behavioral therapy group treatment for clinically significant symptoms of depression and anxiety in COPD patients: a randomized controlled trial

Abstract: CBT group treatment and COPD education can achieve sustainable improvements in QoL for COPD patients experiencing moderate-to-severe symptoms of depression or anxiety.

Cited by 182 publications

References 58 publications

Depression and suicidality in COPD: understandable reaction or independent disorders?

Depression and suicidality in COPD: understandable reaction or independent disorders?

Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk

Systemic manifestations and comorbidities of COPD

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