Copenhagen City Heart Study: longitudinal analysis of ventilatory capacity in diabetic and nondiabetic adults

Lange, Peter; Parner, Jan; Schnohr, Peter; Jensen, Gorm

doi:10.1183/09031936.02.00050502

Cited by 102 publications

(92 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, data are not completely in agreement on this topic, as two other longitudinal studies, based on follow-up periods of 5 and 15 years, respectively, have reported a similar decline in FVC and FEV1 in diabetic and in non-diabetic subjects [94,95]. However, these studies had some limitations.…”

Section: Decline In Lung Function Over Time and Its Clinical Implicationcontrasting

confidence: 45%

“…In the first one, 126 subjects who developed diabetes during the follow-up showed a decline in lung function that was at least twice that of nondiabetics [94]. The second study has limitations in the definition of diabetes, since the diagnosis was either self-reported by the patients or based on a single measurement of fasting blood glucose [95]. Subsequent studies have clearly demonstrated an accelerated decline in lung function in patients with diabetes.…”

Section: Decline In Lung Function Over Time and Its Clinical Implicationmentioning

confidence: 99%

See 1 more Smart Citation

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

146

112

View full text Add to dashboard Cite

■ AbstractSeveral abnormalities of the respiratory function have been reported in patients with type 1 and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Many hypotheses have emerged, and characteristic histological changes have been described in the "diabetic lung", which could explain this abnormal respiratory function. Given the specific abnormalities in diabetic patients, the lung could thus be considered as a target organ in diabetes. Although the practical implications of these functional changes are mild, the presence of an associated acute or chronic pulmonary and/or cardiac disease could determine severe respiratory derangements in diabetic patients. Another clinical consequence of the pulmonary involvement in diabetes is the accelerated decline in respiratory function. The rate of decline in respiratory function in diabetics has been found to be two-to-three times faster than in normal non-smoking subjects, as reported in longitudinal studies. This finding, together with the presence of anatomical and biological changes similar to those described in the aging lung, indicates that the "diabetic lung" could even be considered a model of accelerated aging. This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes.

show abstract

Section: Decline In Lung Function Over Time and Its Clinical Implicationcontrasting

confidence: 45%

Section: Decline In Lung Function Over Time and Its Clinical Implicationmentioning

confidence: 99%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

146

112

View full text Add to dashboard Cite

show abstract

“…The best FEV1 and FVC of three were used in the analyses. Lung function data are reported as a percentage of predicted value according to age, sex and height (FEV1 % pred) [13].…”

Section: Measurementsmentioning

confidence: 99%

Resting heart rate is a predictor of mortality in COPD

et al. 2012

View full text Add to dashboard Cite

The clinical significance of high heart rate in chronic obstructive pulmonary disease (COPD) is unexplored. We investigated the association between resting heart rate, pulmonary function, and prognosis in subjects with COPD.16 696 subjects aged o40 years from the Copenhagen City Heart Study, a prospective study of the general population, were followed for 35.3 years, 10 986 deaths occurred. Analyses were performed using time-dependent Cox-models and net reclassification index (NRI).Resting heart rate increased with severity of COPD (p,0.001). Resting heart rate was associated with both cardiovascular and all-cause mortality across all stages of COPD (p,0.001). Within each stage of COPD, resting heart rate improved prediction of median life expectancy; the difference between ,65 bpm and .85 bpm was 5.5 years without COPD, 9.8 years in mild (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I), 6.7 years in moderate (GOLD stage II) and 5.9 years in severe/very severe COPD (GOLD stage III/IV), (p,0.001). Resting heart rate significantly improved risk prediction when added to GOLD stage (categorical NRI 4.9%, p50.01; category less NRI 23.0%, p,0.0001) or forced expiratory volume in 1 s % predicted (categorical NRI 7.8%, p50.002; category less NRI 24.1%, p,0.0001).Resting heart rate increases with severity of COPD. Resting heart rate is a readily available clinical variable that improves risk prediction in patients with COPD above and beyond that of pulmonary function alone. Resting heart rate may be a potential target for intervention in COPD. @ERSpublications In patients with COPD, an elevated resting heart rate predicts life expectancy and identifies patients at particular risk

show abstract

“…Pulmonary involvement in diabetes is increasingly reported, [26][27][28][29][30][31][32][33] and may have important consequences if patients have co-morbid COPD. Routine spirometry to monitor lung function may therefore be useful in the care of patients with diabetes, particularly those who smoke.…”

Section: Disease Monitoringmentioning

confidence: 99%

Spirometry in primary care case-identification, diagnosis and management of COPD

Price

Crockett

Arne

et al. 2009

Primary Care Respiratory Journal

View full text Add to dashboard Cite

SummaryChronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality worldwide, yet it remains significantly under-diagnosed. Systematic and opportunistic case-identification efforts in primary care, using questionnaires, careful assessment to identify symptoms, and follow-up spirometry, might improve diagnosis rates and enable earlier detection and management of COPD.The aims of spirometry performed for case-identification purposes are to exclude those patients with symptoms but normal lung function and identify those who require more complete investigation for COPD, including 'diagnostic standard' spirometry. Among patients with a confirmed diagnosis of COPD, spirometry monitoring is useful in identifying those with rapid deterioration in lung function who require further assessment. Spirometry in primary care can also support patient education and may encourage smoking cessation and treatment adherence.

show abstract

Copenhagen City Heart Study: longitudinal analysis of ventilatory capacity in diabetic and nondiabetic adults

Cited by 102 publications

References 43 publications

The Diabetic Lung - A New Target Organ?

The Diabetic Lung - A New Target Organ?

Resting heart rate is a predictor of mortality in COPD

Spirometry in primary care case-identification, diagnosis and management of COPD

Contact Info

Product

Resources

About