Copeptin levels predict left ventricular systolic function in STEMI patients

Abstract

In the present study, we aimed to investigate whether copeptin values on admission are related to left ventricle (LV) systolic function and its improvement at 6 months in ST-segment elevation myocardial infarction (STEMI) patients. In this single-center, prospective observational study, we included 122 STEMI patients from January 2016 to November 2016. LV systolic functions in the form of global longitudinal strain (GLS) in addition to conventional echocardiography parameters were evaluated on admission and at 6-month. Serum copeptin levels were determined using an ultrasensitive immunofluorescence assay. The study population was divided into 2 groups according to median values of copeptin. GLS was significantly lower in patients with high copeptin levels compared to those with low copeptin levels at early stage and 6-month (−16% (16–16.5) vs −15% (15–15.5), P < .001 and −18% (18–19) vs −16% (16–16.25), P < .001, respectively). Copeptin values were negatively correlated with an early and 6-month GLS ( r = –0.459 at early stage and r = –0.662 at 6-month). In addition, we observed that copeptin values were negatively correlated with the improvement of GLS at 6-month follow-up ( r = −0.458, P < .001 and r = −0.357, P = .005, respectively). Serum copeptin levels in STEMI patients at the time of admission may predict early and 6-month LV systolic function assessed by two-dimensional GLS. To the best of our knowledge, this study is the first to specifically address the relationship between copeptin values and GLS in STEMI patients.

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“…Acute myocardial infarction categorizes into ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) [153]. STEMI typically arises from coronary atherosclerosis, characterized by a prominent presence of red blood cells and red fibrin thrombi, leading to a complete disruption of coronary blood flow [158]. Notably, approximately half of the STEMI patients might develop symptoms of heart failure between 3-6 months after infarction [159].…”

Predictive value of acoustic cardiography for post-PCI early ventricular remodeling in acute myocardial infarction

“…Early ventricular remodeling usually occurs 24–72 h after AMI and presents clinically as asymptomatic LVSD, but is underdiagnosed 5 , 7 . There are a number of clinical indicators that predict LVSD;copeptin was shown to be a valid indicator 16 ;heart rate-corrected QT interval prolongation to the Global Registry of Acute Coronary Events risk score improves the predictive value for early mortality in patients with acute coronary syndrome 17 ; Of course, there are many other methods of prediction, such as BNP, echocardiography, and magnetic resonance imaging,, but these approaches are expensive, cumbersome and cannot be monitored systematically. Moreover, many patients refused these tests to be performed.…”