Copeptin Release in Cardiac Surgery–A New Biomarker to Identify Risk Patients?

Holm, Jonas; Szabó, Zoltán; Alehagen, Urban; Lindahl, Tomas; Cederholm, Ingemar

doi:10.1053/j.jvca.2017.06.011

Cited by 13 publications

(11 citation statements)

References 25 publications

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“…Instead of AVP, copeptin, the C-terminal part of pre-proAVP is a more stable peptide both in plasma and during storage, and thus easier to measure. As copeptin is secreted in equimolar amounts as AVP it can accordingly be used as a surrogate for AVP release [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…They stated that elevated levels of copeptin were best predicted by natriuretic peptides and kidney function. Holm et al evaluated the reliability of copeptin with NYHA functional class I to IV, BNP levels from 3 to 8.536 pg/ml, and concluded that it is as reliable as BNP [ 10 ]. Apart from Holm et al ., in our research we focused on isolated coronary bypass patients but both studies emphasized the value of copeptin as a predictive biomarker.…”

Section: Discussionmentioning

confidence: 99%

“…According to Holm et al copeptin was independently related to mortality in each symptomatic stage of heart failure; it was most compelling in NYHA functional classes II and III. This is an important finding because NYHA functional classes II and III, the intermediate classes, are more difficult to judge in the ambulatory setting than the more obvious NYHA functional classes I and IV [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic accuracy of copeptin and NT-proBNP level in predicting mortality and postoperative prognosis in coronary surgery with respect to EuroSCORE risk

Göçer¹,

İlkeli²,

Düzgün³

2022

kitp

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Introduction: During the last few years, many modifications in risk stratification of all cardiac surgical patients have been reported based on EuroSCORE. Aim: In this study we aimed to interpret copeptin and NT-proBNP levels in patients who had undergone coronary surgery with respect to EuroSCORE. Material and methods: We investigated the correlation between pre-operative copeptin and NT-proBNP levels with respect to mortality and post-operative complications via EuroSCORE II in the 484 enrolled patients. In terms of analyzing mortality the first 30 days were taken into account and duration of hospital stay was considered for prognosis. The statistical significance of copeptin and NT-proBNP with respect to EuroSCORE II ≥ 2 was studied. Results: The critical threshold levels of mortality for NT-proBNP was 1296 pg/ml and for copeptin was 116 pmol/l in patients whose EuroSCORE II ≥ 2. Mortality increases 9.04-fold in cases with EuroSCORE ≥ 2, 5.04-fold when NT-proBNP level is > 1296 pg/ml. A dramatic outcome was observed in copeptin levels as mortality increased 138.17-fold when copeptin was > 116 pmol/l. Conclusions: Increased levels of copeptin and NT-proBNP negatively affect mortality and complication rates in isolated cardiac surgery patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnostic accuracy of copeptin and NT-proBNP level in predicting mortality and postoperative prognosis in coronary surgery with respect to EuroSCORE risk

Göçer¹,

İlkeli²,

Düzgün³

2022

kitp

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“…(18) çalışmalarında, SvO 2 ≥0.65 ve Pv-aCO 2 <6 mmHg olan hastalarda doku hipoksisi gelişmediğini, mekanik ventilasyon ve yoğun bakımda kalış sürelerinin daha kısa olduğunu bildirmişlerdir. Kalp tipi yağ asidi bağlayıcı protein (H-FABP) son yıllarda en erken yükselen özgün bir biyobelirteç olarak karşımıza çıkmakta ve direkt kardiyak olaylarla ilişkilendirilirken (19) , copeptin de DKD'sini belirlemede özellikle çocuk hastalarda yeni biyobelirteç olarak tanımlanmaktadır (20,21) . Düşük Hb değerleri (Hb<7 g dl -1 ) (22) ve lenfosit değerleri de immün sistemi etkileyerek ile DKD gelişimini artırmaktadır (23) .…”

Section: Laboratuvar Tanı Testleriunclassified

Low Cardiac Output Developed After Open Cardiac Surgery

Özyılkan¹

2020

jarss

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Kalbin dakikada pompaladığı kan hacmi olarak tanımlanan kalp debisi kardiyak performansın değerlendirilmesinde göz önüne alınan en önemli hemodinamik parametrelerden biridir. Açık kalp cerrahisi sonrası hemodinaminin korunması ve yeterli kardiyak performansın sağlanması her zaman kolay olmayabilir. Düşük kalp debisi (DKD) de kardiyak cerrahi sonrası görülebilen ve ciddi hemodinamik değişikliklere yol açarak erken ve geç dönem mortalite ve morbiditeyi artıran durumlardan biridir. Bu derlemede, literatürler eşliğinde DKD'nin öneminin ve yönetiminin gözden geçirilmesi amaçlanmıştır.

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“…To be able to implement novel biomarkers as tools in cardiac surgery and intensive care, it is important that we understand the normal dynamic response of the biomarker throughout the perioperative period. We already know the perioperative kinetics of some biomarkers in clinical use such as NT-proBNP and copeptin (Reyes et al 2005, Holm et al 2018, but for other potential biomarkers data are lacking or incomplete.…”

Section: Introductionmentioning

confidence: 99%

Biomarker dynamics in cardiac surgery: a prospective observational study on MR-proADM, MR-proANP, hs-CRP and sP-selectin plasma levels in the perioperative period

et al. 2020

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Background: For many biomarkers in cardiac surgery, there is a lack of knowledge regarding the normal dynamics of plasma levels during the perioperative course. The aim of this study was to investigate the perioperative dynamics of MR-proADM, MR-proANP, hs-CRP and sP-selectin in cardiac surgery. Method: A prospective observational pilot study with 20 patients scheduled for open cardiac surgery procedures with cardiopulmonary bypass (CPB). Plasma samples were taken for each patient and biomarker during the pre-, per-and postoperative period until Day 6 postoperatively. Results: MR-proADM increased significantly from 0.62 [IQR; 0.54-0.93] nmol/L preoperatively to 1.20 [1.04-1.80] nmol/L postoperative Day 1. MR-proANP increased significantly from 125 [77-152] pmol/L preoperatively to 198 [168-307] pmol/L on weaning from CPB. hs-CRP increased significantly from 2.5 mg/L [0.4-12] preoperatively to peak at 208 mg/L [186-239] postoperative Day 3. The preoperative level of sP-selectin at 23.0 [21.3-26.3] ng/mL initially fell at weaning from CPB, followed by a significant peak of 25.5 [22.7-27.7] ng/mL 8 h postoperatively. Conclusions: The findings in this study may help to understand the physiology of the biomarkers analysed and their response to cardiac surgical trauma including CPB. Furthermore, these findings will guide us in further research on the clinical usefulness of these biomarkers.

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Copeptin Release in Cardiac Surgery–A New Biomarker to Identify Risk Patients?

Cited by 13 publications

References 25 publications

Diagnostic accuracy of copeptin and NT-proBNP level in predicting mortality and postoperative prognosis in coronary surgery with respect to EuroSCORE risk

Diagnostic accuracy of copeptin and NT-proBNP level in predicting mortality and postoperative prognosis in coronary surgery with respect to EuroSCORE risk

Low Cardiac Output Developed After Open Cardiac Surgery

Biomarker dynamics in cardiac surgery: a prospective observational study on MR-proADM, MR-proANP, hs-CRP and sP-selectin plasma levels in the perioperative period

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