Introduction/Aim: Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system that can reduce the quality of life. Personality traits and coping strategies are a significant factor in interpersonal variance regarding quality of life. The aim of this study was to examine relations between personality traits and coping strategies in patients with relapsing-remitting (RR) type MS, and to examine relations of personality traits, coping strategies and quality of life in patients with RR type MS. Methodology: Observational cross-sectional study included 66 patients (34 female and 32 male) with clinically definitive MS, based on the McDonald criteria. The following clinical scales were used to examine personality traits, coping strategies and quality of life: Revised NEO Personality Inventory (NEO-PI-R), Coping Strategies Inventory (CSI) and Multiple Sclerosis Quality of Life (MSQOL-54). Results: The average age of the patients was 41.6 ± 7.1 years. Pearson correlation coefficient shows that with regards to coping strategies, the only positive relation exists with neuroticism (r=.502). The correlation is negative between neuroticism, passive coping strategies and quality of life with physical (r=-.284, p<0.05) and mental health (r=-.289, r=-0.358, p<0.05), meaning that the patients with a higher level of neuroticism, and who rely on passive coping strategies, have a worse quality of life. Conclusion: This research shows the importance of personality traits and coping strategy assessments in patients with RR type MS. Participation in cognitive-behavioral therapy, with an accent on active coping strategies, can improve the quality of life in patients with MS.