The COVID-19 pandemic had a detrimental impact on the mental well-being of young individuals living in rural areas of the Philippines. A survey conducted online, involving 722 students from Isabela State University, Isabela aimed to assess their mental health. The survey gathered information on the students' characteristics, sources of stress, coping mechanisms, and mental health challenges related to the pandemic. Two diagnostic tools, the Patient Health Questionnaire-9, and the Gender Anxiety Disorder-7, were used to evaluate depression and anxiety levels. The results revealed that most 19-to 20-year-old students experienced mild depression and anxiety, with females being more affected than males. Financial constraints hindered access to mental health care, impacting academic performance. COVID-19 symptoms, a lack of counseling, and social isolation were additional stressors. Coping strategies included exercise, a healthy diet, and creative activities. These findings reveal the interconnectedness of isolation, economic challenges, educational setbacks, and mental health effects caused by COVID-19. To address these issues, it is crucial to improve counseling services, provide telehealth training, conduct seminars, implement interventions, offer academic support, and utilize mental health technologies. These measures can bridge the gap between students, parents, and educational institutions. Additionally, future studies should focus on developing tailored therapies for the most affected groups.