The present investigation examined whether smoking outcome expectancies, as measured by the Smoking Consequences Questionnaire (SCQ; Brandon & Baker, 1991), were incrementally related to emotional vulnerability factors among an adult sample of 202 daily cigarette smokers (44.6% women; M age = 23.78 years, SD = 9.69 years). After controlling for cigarettes smoked per day, past 30-day marijuana use, current alcohol consumption, and coping style, negative reinforcement/ negative affect reduction outcome expectancies were significantly associated with greater levels of negative affectivity, emotional dysregulation, and anxiety sensitivity. The observed effects for negative reinforcement/negative affect reduction also were independent of shared variance with other outcome expectancies. Negative personal consequences outcome expectancies were significantly and incrementally related to anxiety sensitivity, but not negative affectivity or emotional dysregulation. Findings are discussed in terms of the role of negative reinforcement/negative affect reduction smoking outcome expectancies and clinically-relevant negative emotional vulnerability for better understanding cigarette smoking-negative mood problems.Correspondence concerning this article should be addressed to Michael J. Zvolensky, Ph.D., Dr. Zvolensky can be contacted at The University of Vermont, Department of Psychology, 2, Colchester Avenue, John Dewey Hall, Burlington,. Electronic mail may be sent to Michael.Zvolensky@uvm.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 2 Although not a primary aim of the current study, exploratory analyses focused on positive affectivity were completed for comparative purposes. These analyses were completed in an identical fashion to those reported in the paper except positive affectivity was employed as the dependent variable. Here, predictor variables accounted for 22.1% of the overall variance for positive affectivity [F(9, 198) = 5.95, p < .001]. Level one of the model accounted for 17.1% of the variance, with significant contributions by the emotional processing and emotional expression subscales (β = .30, p < .001 and β = .16, p < .05, respectively). Level two of the model accounted for an additional 5% of the variance, with the appetite control subscale being the only significant predictor (β = −.16, p < .05). There is a recent and increasingly well-documented association between cigarette smoking and depressive and anxiety symptoms and disorders (Morrell & Cohen, 2006;Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007;Patton, Carlin, Coffey, Wolfe, Hibbert, & ...