The majority of the large number of existing land use models lack a proper validation, often because of data problems. Moreover, despite recognition of the necessity to incorporate a multi-scale analysis, scale dependencies are normally not considered during validation. In this paper, a multi-scale land use change modelling framework, conversion of land use and its effects (CLUE), is calibrated for Costa Rica and validated at five spatial resolutions for Honduras and Costa Rica. Both countries experienced locally very strong actual land use changes. Calibration runs show that the model is very sensitive to changes in the autonomous development parameter, which defines the influence of the finest resolution. Validation results are very satisfactory for both countries. Especially, changes in major land use types are reproduced with the model. Changes in localised land use types are more difficult to project. The magnitude of gains and magnitude of losses are slightly underestimated in all cases. The multi-scale validation demonstrates that results improve strongly, and exponentially, with decreasing spatial resolution. Strong reduction of the number of observations results in a correlation between actual and modelled changes that approximates the perfect value of 1. The study demonstrates that the CLUE modelling framework can reproduce changes as they took place in Central America in the 1970s and 1980s, and shows how conclusions can differ depending on the scale at which validation is performed.