The purpose of this article is to assist rehabilitation researchers in making decisions about the design and conduct of stress and coping research. The authors offer a selective review of the stress and coping literatures, with a focus on rehabilitation-specific work. The authors first address stress, focusing on different definitions and on how it relates to adaptation, and then consider coping, focusing on the levels at which coping operates, its relation to features of the situation, and its influence on adjustment. The authors urge researchers to collect additional data, including assessing changes over time, and to examine multiple aspects of stressful experiences to better capture the complexity of stress and coping processes.Researchers should specify the nature of the coping construct used, use assessment methods clearly linked to the facet of the coping construct being examined, and investigate specific mechanisms by which coping influences rehabilitation outcomes.As a final word, there is bad news and good news. The bad news is the lack of coherence and organization in the field [of coping] . . . . The good news is the wealth of studies . . . adds robustness to the concept that coping style, broadly conceived, is a potent factor in adjustment.