Coping with stress in rats and mice: Differential peptidergic modulation of the amygdala-lateral septum complex

Koolhaas, J.M.; Everts, H.; Ruiter, A.J.H. de; Boer, Sietse F. de; Bohus, B.

doi:10.1016/s0079-6123(08)61586-1

Cited by 97 publications

(52 citation statements)

References 60 publications

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“…Previous work has shown VP increases agonistic behavior in several rodent species, including hamsters and voles. [8][9][10][11] Furthermore, specific V1aR agonists and antagonists also affect aggression, 9,18,19 suggesting that the V1aR mediates some of these effects. We have now shown that V1b receptors must play a role in mediating VP's effects on aggression.…”

Section: Discussionmentioning

confidence: 99%

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Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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Increased aggression is commonly associated with many neurological and psychiatric disorders. Current treatments are largely empirical and are often accompanied by severe side effects, underscoring the need for a better understanding of the neural bases of aggression. Vasopressin, acting through its 1a receptor subtype, is known to affect aggressive behaviors. The vasopressin 1b receptor (V1bR) is also expressed in the brain, but has received much less attention due to a lack of specific drugs. Here we report that mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition. By contrast, they perform normally in all the other behaviors that we have examined, such as sexual behavior, suggesting that reduced aggression and social memory are not simply the result of a global deficit in sensorimotor function or motivation. Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemosensory signals to the brain. We suggest that V1bR antagonists could prove useful for treating aggressive behavior seen, for example, in dementias and traumatic brain injuries. Molecular Psychiatry (2002) 7, 975-984.

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Section: Discussionmentioning

confidence: 99%

“…5 Vasopressin (VP) is implicated in agonistic behavior in taxonomically diverse groups including mammals (eg hamsters, voles) and fish (eg wrasse). [6][7][8][9][10][11] Even in humans, a life history of aggression against others correlates with increased CSF levels of VP. 12 Vasopressin also modulates social memory in rodents.…”

Section: Introductionmentioning

confidence: 99%

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

et al. 2002

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“…The effect of BMI on Fos expression in the BNST and the LSV, two limbic structures closely associated with emotion and defensive reactions (for reviews, see Koolhaas et al, 1998;Garcia, 2002;Walker et al, 2003;Herman et al, 2005), provide an interesting contrast. A variety of stress paradigms have been reported to increase Fos expression in the BNST (Campeau and Watson, 2000;Greenwood et al, 2003;Ma and Morilak, 2004;Mantella et al, 2004;Bali et al, 2005, Kiyokawa et al, 2005Spencer et al, 2005) and the LSV (Cullinan et al, 1995;Imaki et al, 1995;Lino-de-Oliveira et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…We employed a reduced volume of injection (100 nL), and a dose of BMI (10 pmol) previously shown to produce relevant effects that are anatomically specific to the DMH (DeNovellis et al, 1995;Bailey and DiMicco, 2001;Zaretskaia et al, 2002). Areas selected for quantitative analysis included: the bed nucleus of the stria terminalis (BNST), also examined in the study of Silveira and colleagues (1995), and the ventral region of the lateral septal nucleus (LSV), two forebrain regions that (1) receive afferents from and send efferents to the DMH (ter Horst and Luiten, 1986;Thompson et al, 1996;Thompson and Swanson, 1998), (2) have been implicated in behavioral and neuroendocrine responses to stress and anxiety (Koolhaas et al, 1998;Ebner et al, 1999;Cecchi et al, 2002;Khoshbouei et al, 2002;Walker et al, 2003) and (3) where experimental stress has been reported to increase Fos expression (LSV: Sharp et al, 1991;Duncan et al, 1993;Beck and Fibiger, 1995;Imaki et al, 1995;BNST: Campeau and Watson, 2000;Ma and Morilak, 2004;Spencer and Day, 2004); the parvocellular and magnocellular regions of the PVN; the nucleus tractus solitarius (NTS) and the ventrolateral medulla (VLM), key brainstem regions involved in the central control of sympathetic activity regulating cardiovascular function (Ross et al, 1984;Sved et al, 1985;Willette et al, 1987;Agarwal et al, 1990); and the rostral raphe pallidus (rRP), a brain region implicated in the tachycardia evoked by chemical stimulation of the DMH Cao et al, 2004) and by experimental air jet stress (Zaretsky et al, 2003). In this study, microinjections of BMI into the DMH were unilateral.…”

Section: Introductionmentioning

confidence: 99%

Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamus

et al. 2008

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Activation of neurons in the dorsomedial hypothalamus (DMH) appears to play an important role in signaling the excitation of brain regions responsible for experimental fever and for many of the physiological and behavioral changes seen in experimental stress or anxiety in rats. Here, we examined the effect of disinhibition of the DMH by unilateral microinjection of bicuculline methiodide (BMI) on Fos expression in selected regions of the brain that have been implicated in anxiety and responses to stress and fever in rats. Disinhibition of the DMH resulted in dramatic increases in local Fos expression and also increased the numbers of Fos-positive neurons in the lateral septal nucleus and in both the parvocellular and magnocellular subdivisions of the paraventricular nucleus, with greater increases ipsilateral to the injection site in the DMH. However, microinjection of BMI had no significant effect on Fos expression in the bed nucleus of the stria terminalis, another forebrain area implicated in stress and anxiety. In the brainstem, disinhibition of the DMH increased Fos expression in the nucleus tractus solitarius and the ventrolateral medulla bilaterally with greater increases again ipsilateral to the site of the microinjection, and also in the midline rostral raphe pallidus. Thus, disinhibition of neurons in the DMH in conscious rats results in increases in Fos expression in selected forebrain and brainstem regions that have been implicated in stress-induced physiological changes, anxiety, and experimental fever.

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“…Studies in both rats and mice show that the variation of the lateral septum AVP system within males is as great as that between males and females. Indeed, there is a negative correlation between AVP content and the extent of septal AVP innervation and aggression in male mice and a positive correlation between AVP levels in the septum in rats showing high performance in footshock-induced brightness discrimination (for review, see Koolhaas et al, 1998). Moreover, it has been reported recently that endogenous AVP released in the lateral septum during the forced swim test reduces immobility, whereas the application of a potent V1 antagonist by reverse microdialysis produced the opposite results (Ebner et al, 1999), suggesting that septal AVP is involved in stress-coping behaviors.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Hormonal Modulation of Anxiety Measured with Light-Enhanced Startle: Possible Role for Arginine Vasopressin in the Male

Toufexis¹,

Davis²,

Hammond³

et al. 2005

J. Neurosci.

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Increased acoustic startle in the presence of bright ambient light, a phenomenon called light-enhanced startle (LES), is dependent on the bed nucleus of the stria terminalis. In contrast to gonadally intact male rats, LES was seen reliably in castrated male rats and in female rats, although it fluctuated significantly with reproductive state. Replacement with testosterone (T) or combined estradiol (E2) and dihydrotestosterone (DHT), but not with either E2 or DHT alone, attenuated LES in castrated rats. However, replacement with T or E2 in ovariectomized rats did not decrease LES. In contrast, no sex difference was seen in the central amygdala-dependent acquisition or expression of fear-potentiated startle. In addition, T did not reduce expression of fear-potentiated startle in castrated rats. T-replaced castrated males injected centrally with mixed arginine vasopressin (AVP) V1a/b receptor antagonists daily throughout the replacement period failed to show a reduction in the expression of LES. These data suggest that T attenuates LES, but not fear-potentiated startle, through a mechanism that may involve AVP.

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Coping with stress in rats and mice: Differential peptidergic modulation of the amygdala-lateral septum complex

Cited by 97 publications

References 60 publications

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Vasopressin V1b receptor knockout reduces aggressive behavior in male mice

Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamus

Sex Differences in Hormonal Modulation of Anxiety Measured with Light-Enhanced Startle: Possible Role for Arginine Vasopressin in the Male

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