Introduction: The concept of lifestyle is closely related to the concept of health. Several studies have been conducted on the dimensions of health-related lifestyle in patients living with human immunodeficiency virus/acquired immunodeficiency disease (HIV/AIDS), but none has comprehensively addressed it. This study is carried out for the purposes of defining and clarifying its concept in HIV/AIDS patients. Material and methods: This study used a hybrid model of concept analysis comprising three phases; namely, a theoretical phase, field work phase, and a final analysis phase. To find relevant literature, an electronic search of valid databases was utilised using keywords related to the concept of healthrelated lifestyle. In the field work phase semi-structured interviews were performed with 12 people living with HIV/AIDS. The conventional content analysis was used in two theoretical and field work phases, and the results were combined in the final analysis phase. Results: From the sum of 1362 gained titles in theoretical phase, 71 texts were analysed and five attributes were extracted, including physical health behaviours, social and recreational activities, sexuality and fertility health, health-centred care, and distress and coping. The most important consequence of a healthy lifestyle in literature review is enhanced physical and mental health. Working in the field phase added a social interactions category to the feature of the concept. In the third phase with the combination of the results of two phases, the final definition of the concept was presented. Conclusions: Health-related lifestyle in HIV/AIDS patients is a set of behaviours that have different physio-psycho-social dimensions that people display in their individual and social lives, thereby providing their physical and mental health.