Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy

Clausen, Chris; Skands, Gustav Erik; Bertelsen, Christian Vinther; Svendsen, Winnie Edith

doi:10.3390/mi6010110

Cited by 43 publications

(31 citation statements)

References 11 publications

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“…Numerical modeling is a powerful tool for the design and optimization of lab-on-chip devices (e.g, [27,28,29,30]), and has been extensively used in impedance cytometry (e.g., [17,31,15,32]). In this work, an original virtual laboratory has been presented, enabling the generation of data streams closely mimicking experimental traces, and easily adaptable to different designs of microfluidic impedance chips.…”

Section: Discussionmentioning

confidence: 99%

“…Vertical 3D-electrodes have also been proposed (e.g., [10,11]). Chips with coplanar configuration are especially attractive, because coplanar electrodes can be easily patterned yielding miniaturized, reproducible, and ultimately low-cost devices [12,13,14,15,16]. However, their accuracy is challenged by the dependence of the measured signal on particle trajectory within the interrogation volume [17,18], that manifests itself as an error in the estimated particle size ("electrical" diameter), unless any kind of focusing system is used.…”

Section: Introductionmentioning

confidence: 99%

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Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout

Caselli

Bisegna

2017

Medical Engineering & Physics

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The performance of a novel microfluidic impedance cytometer (MIC) with coplanar configuration is investigated in silico. The main feature of the device is the ability to provide accurate particle-sizing despite the well-known measurement sensitivity to particle trajectory. The working principle of the device is presented and validated by means of an original virtual laboratory providing close-to-experimental synthetic data streams. It is shown that a metric correlating with particle trajectory can be extracted from the signal traces and used to compensate the trajectory-induced error in the estimated particle size, thus reaching high-accuracy. An analysis of relevant parameters of the experimental setup is also presented.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout

Caselli

Bisegna

2017

Medical Engineering & Physics

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“…The use of capacitive interdigitated electrodes (IDE) has been discussed already in several papers, ranging from gas sensors to liquid sensors [17,18,21]. This concept has the ability for miniaturization, since the electrodes can be made using complementary metal oxide semiconductor (CMOS) compatible technologies, and the read-out electronics only require a small Printed Circuit Board (PCB).…”

Section: Capacitive Interdigitated Electrodesmentioning

confidence: 99%

A Versatile Capacitive Sensing Platform for the Assessment of the Composition in Gas Mixtures

Sweelssen¹,

Blokland²,

Rajamäki

et al. 2020

Micromachines

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The energy market is facing a major transition, in which natural gas and renewable gasses will play an important role. However, changing gas sources and compositions will force the gas transporters, gas engine manufacturers, and gas grid operators to monitor the gas quality in a more intensive way. This leads to the need for lower cost, smaller, and easy to install gas quality sensors. A new approach is proposed in this study that is based on the chemical interactions of the various gas components and responsive layers applied to an array of capacitive interdigitated electrodes. For Liquid Natural Gas (LNG), containing a relative high concentration of higher hydrocarbons, an array of ten capacitive chips is proposed, that is sufficient to calculate the full composition, and can be used to calculate energy parameters, such as Wobbe Index, Calorific Value, and Methane Number. A first prototype was realized that was small enough to be inserted in low and medium pressure gas pipes and LNG engine fuel lines. Adding the pressure and temperature data to the chip readings enables the determination of the concentrations of the various alkanes, hydrogen, nitrogen, and carbon dioxide, including small fluctuations in water vapor pressure. The sensitivity and selectivity of the new sensor is compared to a compact analyzer employing tunable filter infrared spectrometry.

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“…A lock-in amplifier with a built-in signal generator (HF2LI, Zurich Instruments) was connected to the microelectrodes via a custommade low noise instrumentation amplifier circuit. We used the commonly employed MIC electrode architecture: a three coplanar electrodes configuration within the microfluidic chip representing two electrode pairs (Clausen et al 2015b;Errico et al 2017;Gawad et al 2001). An excitation AC signal was applied to the source electrode (Es) via the signal-output port of the lock-in amplifier.…”

Section: Microfluidic Impedance Cytometry Setupmentioning

confidence: 99%

Integrated Field’s metal microelectrodes based microfluidic impedance cytometry for cell-in-droplet quantification

Panwar

Roy

2018

Preprint

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Microfluidic impedance cytometry (MIC) provides a non-optical and label-free method for single cell detection and classification in microfluidics. However, the cleanroom intensive infrastructure required for MIC electrode fabrication limits its wide implementation in microfluidic analysis. To bypass the conventional metal (platinum) electrode fabrication protocol, we fabricated coplanar 'in-contact' Field's metal (icFM) microelectrodes in multilayer elastomer devices with a single photolithography step. Our icFM microelectrodes displayed excellent and comparable performance to the platinum electrodes for detection of single erythrocytes with a lock-in amplifier based MIC setup. We further characterized it for water-in-oil droplets generated in a T-junction microfluidic channel and found high sensitivity and long-term operational stability of these electrodes. Finally, to facilitate droplet based single cell analysis, we demonstrate detection and quantification of single cells entrapped in aqueous droplets.

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Coplanar Electrode Layout Optimized for Increased Sensitivity for Electrical Impedance Spectroscopy

Cited by 43 publications

References 11 publications

Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout

Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout

A Versatile Capacitive Sensing Platform for the Assessment of the Composition in Gas Mixtures

Integrated Field’s metal microelectrodes based microfluidic impedance cytometry for cell-in-droplet quantification

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