Copoly(γ,dl-glutamate)s containing short and long linear alkyl side chains

Morillo, Margarita; Ilarduya, Antxon Martı́nez de; Muñoz‐Guerra, Sebastián

doi:10.1016/j.polymer.2003.10.001

Cited by 13 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comb‐like polymer is a special kind of graft‐copolymer having relatively high grafting degree and long side chains. Aggregation structure of comb‐like polymers has been extensively investigated due to their special chemical structures and physical properties . The most special physical property of the comb‐like polymers is that they can aggregate into layered structure .…”

Section: Introductionmentioning

confidence: 99%

Side chain packing states of chitosan‐based supramolecular derivatives containing long alkyl side chains

Liu

Lyu

Xiang

et al. 2020

Polymer Crystallization

View full text Add to dashboard Cite

A series of chitosan-based supramolecular comb-like polymers containing long alkyl side chain were prepared. They aggregated into layered structure. When the alkyl side chain was longer than 16 carbons, the long alkyl side chains exhibited crystallization behavior. During heating process, the packing structure of comb-like polymers with side chain length from 10 to 20 showed a peculiar behavior of volume shrinkage, but that of samples with much longer side chain (>22) expanded. Such results could be attributed to the different packing structure of side chains when they possess different length. Both the steric hindrance and the tendency of side chain aggregation affect the packing state of alkyl side chains together.

show abstract

Section: Introductionmentioning

confidence: 99%

Side chain packing states of chitosan‐based supramolecular derivatives containing long alkyl side chains

Liu

Lyu

Xiang

et al. 2020

Polymer Crystallization

View full text Add to dashboard Cite

show abstract

“…Hydrogen bonding was observed in Figure from the shift in the carbonyl resonance frequency as well as the disappearance of the isolated silanol peak. The effect of main chain mobility and structure on side chain crystallinity has also been extensively studied . It has been reported that chain stiffness retards the attainment of crystallinity .…”

Section: Discussionmentioning

confidence: 99%

“…The effect of main chain mobility and structure on side chain crystallinity has also been extensively studied. 17,32,[35][36][37][38][39][40] It has been reported that chain stiffness retards the attainment of crystallinity. 40 The retardation of crystallization was evident in the smallest adsorbed amount sample (0.74 mg/ m 2 ) which showed effectively no crystallinity.…”

Section: Discussionmentioning

confidence: 99%

Disruptions in the crystallinity of poly(lauryl methacrylate) due to adsorption on silica

Arua

Blum

2017

J Polym Sci B Polym Phys

View full text Add to dashboard Cite

The effects of adsorption of poly(lauryl methacrylate) (PLMA), a side-chain crystalline polymer, on silica were investigated. Fourier transform infrared spectroscopy and differential scanning calorimetry (DSC) measurements were made on both bulk and adsorbed PLMA. The reversible heat flow rates were observed as a function of temperature and the degree of crystallinity of the samples determined based on the broad melting transitions of the side chains in the surface samples. It was found that adsorption caused a disruption of the side-chain crystallinity primarily in the tightly bound layer of the polymer, but did not significantly affect its glass transition temperature. A change in the packing of the hydrophobic side chains, as a result of adsorption, was also observed for the tightly adsorbed polymer. These results indicated that PLMA side chains in proximity to the silica surface have different properties from those in bulk PLMA.

show abstract

“…According to a previous NMR study carried out by us on ethylation of PGGA using a similar method, the co-polymers are expected to have a random microstructure [17]. All these compounds were non- water soluble and their hydrophilicity and wetting properties were found to decrease with the increase in content and size of the alkyl group as revealed by the measured contact angles.…”

Section: Synthesis Of Polyglutamatesmentioning

confidence: 92%

“…It should be noticed that homo-polymers PAAG-Et and PAAG-Octd are known to crystallize readily in ordered three-and two-dimensional arrays, respectively [18]. It is also known that the octadecyl side-chains of co-polymers coPAAG-(Et x Octd y ) are crystallized for a fair range of co-polymer compositions [17]. The fact that the whole set of coPAAG-(R x H y )s appear unable to display ordering should be associated to the strong disturbing effect of the carboxylic group on the structure.…”

Section: Synthesis Of Polyglutamatesmentioning

confidence: 99%

Nanoparticles Made of Microbial Poly(γ-glutamate)s for Encapsulation and Delivery of Drugs and Proteins

Portilla-Arias

García‐Alvarez

Ilarduya

et al. 2009

Journal of Biomaterials Science, Polymer Edition

View full text Add to dashboard Cite

This study focused on the preparation and evaluation of nanoparticles made of alkyl esters of microbial poly(gamma-glutamic acid) (PGGA) to be used as drugs and proteins carrier and delivery systems. Racemic PGGA of bacterial origin was fully methylated or partially esterified to render non-water-soluble polymers. A set of co-polymers containing poly(glutamic acid) and ethyl, hexyl, dodecyl and octadecyl glutamate units with alkyl contents of 50 and 75% was prepared. Spherical nanoparticles with a diameter of 200-250 nm and a narrow distribution were generated from the alkylated polymers by the precipitation-dialysis method. These nanoparticles readily degraded hydrolytically upon incubation in simulated physiological medium at a rate dependent on the alkylation degree and the length of the alkyl group. All these nanoparticles were able to encapsulate efficiently erythromycin. Those made of carboxyl containing polyglutamates were also effective to load alpha-chymotrypsin. The release of such compounds from nanoparticles upon incubation proceeded essentially following the same profile that is followed in the hydrolysis of the corresponding substrate polymers. The loss of enzyme activity of the incubated protein diminished significantly upon encapsulation in these systems.

show abstract

Copoly(γ,dl-glutamate)s containing short and long linear alkyl side chains

Cited by 13 publications

References 27 publications

Side chain packing states of chitosan‐based supramolecular derivatives containing long alkyl side chains

Side chain packing states of chitosan‐based supramolecular derivatives containing long alkyl side chains

Disruptions in the crystallinity of poly(lauryl methacrylate) due to adsorption on silica

Nanoparticles Made of Microbial Poly(γ-glutamate)s for Encapsulation and Delivery of Drugs and Proteins

Contact Info

Product

Resources

About