Copolythiophene-based water-gated organic field-effect transistors for biosensing

Suspène, Clément; Piro, Benoı̂t; Reisberg, S.; Pham, Minh‐Chau; Toss, Henrik; Berggren, Magnus; Yassar, Abderrahim; Horowitz, Gilles

doi:10.1039/c3tb00525a

Cited by 45 publications

(34 citation statements)

References 28 publications

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“…Still with the objective to functionalize the semiconductor and impede its doping by ions present in the electrolyte, Cotrone et al described a non-covalent approach using a phospholipid bilayer [93]. They compared the electric performances of the EGOFET including a phospholipid film to those with the organic semiconductor directly in contact with the gating solution.…”

Section: Non-covalent Functionalization Of the Semiconductormentioning

confidence: 99%

“…Kergoat et al [91], Sinno et al [59] and Toss et al [92] used chemical reactions to bind P3HT with another polymer to make new semiconductor polymer blends with improved stability, electronic performances and biocompatibility. Suspène et al used peptidic coupling to directly graft biotin on P3HT in order to make a proof-of-concept streptavidin or avidin sensor [93]. All these approaches impose making compromises between the electrical and immobilization properties.…”

Section: Poly(25-bis(3-alkylthiophen-2-yl)thieno[32-b]-thiophene) (mentioning

confidence: 99%

“…Suspene et al reported in 2013 on the sensing of streptavidin with an EGOFET using a copolymer of P3HT, P3HT-COOH and biotinylated P3HT ( Figure 11A) as the active sensing and semiconducting material [93]. The biotin-streptavidin couple was chosen as a proof-of-concept, for its extremely low dissociation constant.…”

Section: P3ht-based Egofet For Protein (Streptavidin) Detectionmentioning

confidence: 99%

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Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

2016

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Electrolyte-gated organic field-effect transistors have emerged in the field of biosensors over the last five years, due to their attractive simplicity and high sensitivity to interfacial changes, both on the gate/electrolyte and semiconductor/electrolyte interfaces, where a target-specific bioreceptor can be immobilized. This article reviews the recent literature concerning biosensing with such transistors, gives clues to understanding the basic principles under which electrolyte-gated organic field-effect transistors work, and details the transduction mechanisms that were investigated to convert a receptor/target association into a change in drain current.

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Section: Non-covalent Functionalization Of the Semiconductormentioning

confidence: 99%

Section: Poly(25-bis(3-alkylthiophen-2-yl)thieno[32-b]-thiophene) (mentioning

confidence: 99%

Section: P3ht-based Egofet For Protein (Streptavidin) Detectionmentioning

confidence: 99%

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Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

2016

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“…Three different polythiophene derivatives with various ratio of anchoring groups are compared: poly-(3-hexyl-thiophene) P3HT (Figure 2a), poly-(3-carboxy-pentyl-thiphene) P3CPT (Figure 2b) and a random co-polymer P3HT-co-Poly-(3-ethoxypentanoic acid-thiophene) (monomer ratio 1:6, i.e. ~15% -COOH side chain end groups, P3HT-COOH15 [27][28]) (Figure 2c) are compared.…”

Section: Introductionmentioning

confidence: 99%

On the mode of operation in electrolyte-gated thin film transistors based on different substituted polythiophenes

Toss¹,

Suspène²,

Piro³

et al. 2014

Organic Electronics

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Organic Thin Film Transistors (OTFT), gated through an aqueous electrolyte, have extensively been studied as sensors in various applications. These water-gated devices are known to work both as electrochemical (Organic ElectroChemical Transistor - OECT) and field-effect (Organic Field-Effect Transistor - OFET) devices. To properly model and predict the response of water-gated OTFT sensors it is important to distinguish between the mechanism, field-effect or electrochemical, by which the transistor is modulated and thus how the gate signal can be affected by the analyte. In this present study we explore three organic polymer semiconductors, poly-(3-hexyl-thiophene) (P3HT), poly-(3-carboxypentyl-thiphene) (P3CPT) and a co-polymer P3HT-co-poly-(3-ethoxypentanoic acid-thiophene) (monomer ratio 1:6, P3HT-COOH15) in water-gated OTFT structures. We report a set of transistor characteristics, including standard output parameters, impedance spectroscopy and current transients, to investigate the origin of the mode of operation in these water-gated OTFTs. Impedance characteristics, including both frequency and voltage dependence, were recorded for capacitor stacks corresponding to the gate/electrolyte/semiconductor/source structure. It is shown that P3HT as well as P3HT-COOH15 both can function as semiconductors in water gated OTFT devices operating in field-effect mode. P3CPT on the other hand shows typical signs of electrochemical mode of operation. The -COOH side group has been suggested as a possible anchoring site for biorecognition elements in EGOFET sensors, rendering P3HT-COOH15 a possible candidate for such applications.

Funding Agencies|European Union [248728]; Swedish Government (SFO-AFM); Onnersjo Foundation (Holmen); Knut and Alice Wallenberg Foundation (Power Papers); VINNOVA (PEA)

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“…[53] Weiterhin wurde auch ein Polythiophen-Copolymer mit biotinylierten Seitenketten, die Avidin-oder Streptavidin-Moleküle einfangen kçnnen, in EG-TFTs vorgeschlagen. [54] Vorkurzem wurden gentechnisch veränderte chimäre Avidin-Moleküle mit C-terminalen Cysteinresten direkt auf einer Goldoberfläche immobilisiert. Die gebildete Bioschicht hat eine hçhere Bindungskapazität für biotinylierte Moleküle als auf der gleichen Oberfläche verankertes Wildtyp-Avidin.…”

Section: Wechselwirkung Zwischen Avidin Oder Streptavidin Und Biotinunclassified

Druckbare Bioelektronik zur Untersuchung funktioneller biologischer Grenzflächen

et al. 2015

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Dünnschichttransistoren können als bioelektronische Bauelemente genutzt werden, um solche Aufgaben auszuführen wie Erkennung oder Steuerung der Freisetzung biologischer Spezies sowie Umwandlung der elektrischen Aktivität von Zellen oder sogar Organen wie des Gehirns. Organische Materialien sowie Graphen oder Zinkoxid werden als druckbare Halbleiterschicht eingesetzt, was zu leistungsfähigen kostengünstigen bioelektronischen Sensoreinheiten führen kann, die möglicherweise sehr nützlich für Vor‐Ort‐Anwendungen sind. Von Interesse sind unter anderem die elektrolytgesteuerten Transistoren, da sie aufgrund der hohen Kapazität der Ladungsdoppelschichten als kapazitätsmodulierte Bauelemente betrieben werden können. Speziell die Kapazität der Bioschicht, die in einer Reihe von Kondensatoren geringer ist, beeinflusst den Ausgangsstrom des Bauelementes. Solch ein Phänomen ermöglicht eine äußerst hohe Empfindlichkeit gegen sehr schwache Wechselwirkungen. Sämtliche Aspekte, die diese Vorgänge bestimmen, werden besprochen.

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Copolythiophene-based water-gated organic field-effect transistors for biosensing

Cited by 45 publications

References 28 publications

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

Electrolytic Gated Organic Field-Effect Transistors for Application in Biosensors—A Review

On the mode of operation in electrolyte-gated thin film transistors based on different substituted polythiophenes

Druckbare Bioelektronik zur Untersuchung funktioneller biologischer Grenzflächen

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