Copper

Coles, Martyn P.

doi:10.1039/c2ic90022j

Cited by 2 publications

(2 citation statements)

References 85 publications

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“… 3 , 4 Copper has unique chemical characteristics that make the use of its radiometals particularly interesting. 5 Copper has many important biological roles in vivo , such as electron transfer, catalysis, and structural shaping. 6 Many copper-containing compounds are biologically active and have anti-inflammatory and antiproliferative properties.…”

Section: Introductionmentioning

confidence: 99%

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Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals

Cai

Anderson

2013

Labelled Comp Radiopharmac

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The development of chelating agents for copper radionuclides in positron emission tomography radiopharmaceuticals has been a highly active and important area of study in recent years. The rapid evolution of chelators has resulted in highly specific copper chelators that can be readily conjugated to biomolecules and efficiently radiolabeled to form stable complexes in vivo. Chelators are not only designed for conjugation to monovalent biomolecules but also for incorporation into multivalent targeting ligands such as theranostic nanoparticles. These advancements have strengthened the role of copper radionuclides in the fields of nuclear medicine and molecular imaging. This review emphasizes developments of new copper chelators that have most greatly advanced the field of copper-based radiopharmaceuticals over the past 5 years.

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Section: Introductionmentioning

confidence: 99%

“…The development of bifunctional chelators plays a pivotal role in metal‐based radiopharmaceuticals . Copper has unique chemical characteristics that make the use of its radiometals particularly interesting . Copper has many important biological roles in vivo , such as electron transfer, catalysis, and structural shaping .…”

Section: Introductionmentioning

confidence: 99%