Copper and cadmium administration induce toxicity and oxidative stress in the marine flatworm Macrostomum lignano

Ma, Yuanyuan; Rivera‐Ingraham, Georgina A.; Nommick, Aude; Bickmeyer, Ulf; Roeder, Thomas

doi:10.1016/j.aquatox.2020.105428

Cited by 16 publications

(5 citation statements)

References 80 publications

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“…A survey of the literature from the past 25 years indicated several studies where the highest exposure concentrations in toxicity tests have exceeded 5 mg Cu L À1 (e.g. Valdovinos and Zuniga 2002;Ma et al 2020;Wang et al 2020). Toxicity endpoints have also been reported at concentrations higher than the solubility limits of copper in seawater determined in the current study.…”

Section: Relevance To Toxicity Testingsupporting

confidence: 49%

Geochemical factors affecting the solubility of copper in seawater

et al. 2021

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Environmental context. Many trace metals, including copper, are only sparingly soluble in seawater and may exist in both dissolved and particulate forms (e.g. as precipitates). Aquatic organisms may experience different toxic effects from exposure to dissolved and particulate trace metals. This study investigates how concentration, reaction time and changes to precipitate composition/mineral formation affect copper solubility in seawater, thus influencing metal bioavailability and toxicity in the field and laboratory.

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Section: Relevance To Toxicity Testingsupporting

confidence: 49%

Geochemical factors affecting the solubility of copper in seawater

et al. 2021

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“…Animal culturing. Animal culturing was essentially done as described earlier 76 . Macrostomum lignano (DV1 line) was originally collected from sediments of the Adriatic Sea and obtained from the Department of Zoology and Limnology, University of Innsbruck, Austria, and then reared in petri dishes, fed with Nitszchia curvilineata and cultured in Guillard's F/2 medium (Sigma G0154).…”

Section: Methodsmentioning

confidence: 99%

The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity

Sieber

et al. 2023

Commun Biol

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The close association between animals and their associated microbiota is usually beneficial for both partners. Here, we used a simple marine model invertebrate, the flatworm Macrostomum lignano, to characterize the host-microbiota interaction in detail. This analysis revealed that the different developmental stages each harbor a specific microbiota. Studies with gnotobiotic animals clarified the physiological significance of the microbiota. While no fitness benefits were mediated by the microbiota when food was freely available, animals with microbiota showed significantly increased fitness with a reduced food supply. The microbiota of M. lignano shows circadian rhythmicity, affecting both the total bacterial load and the behavior of specific taxa. Moreover, the presence of the worm influences the composition of the bacterial consortia in the environment. In summary, the Macrostomum-microbiota system described here can serve as a general model for host-microbe interactions in marine invertebrates.

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“…Despite the fact that a considerable part of the invertebrate community is involved in research about animal models for human diseases [24,[30][31][32][33], the advantage of using available model organisms for DNT testing has hardly been recognized. Except for many applied studies of ecotoxicological risk assessment [34][35][36], which are not in the focus of my review, the issue of DNT did not catch the attention of most invertebrate developmental neurobiologists. This is quite understandable because, even in toxicology, DNT is among the most difficult and least-studied areas [10].…”

Section: Introductionmentioning

confidence: 98%

Looking at Developmental Neurotoxicity Testing from the Perspective of an Invertebrate Embryo

Bicker¹

2022

IJMS

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Developmental neurotoxicity (DNT) of chemical compounds disrupts the formation of a normal brain. There is impressive progress in the development of alternative testing methods for DNT potential in chemicals, some of which also incorporate invertebrate animals. This review briefly touches upon studies on the genetically tractable model organisms of Caenorhabditis elegans and Drosophila melanogaster about the action of specific developmental neurotoxicants. The formation of a functional nervous system requires precisely timed axonal pathfinding to the correct cellular targets. To address this complex key event, our lab developed an alternative assay using a serum-free culture of intact locust embryos. The first neural pathways in the leg of embryonic locusts are established by a pair of afferent pioneer neurons which use guidance cues from membrane-bound and diffusible semaphorin proteins. In a systematic approach according to recommendations for alternative testing, the embryo assay quantifies defects in pioneer navigation after exposure to a panel of recognized test compounds for DNT. The outcome indicates a high predictability for test-compound classification. Since the pyramidal neurons of the mammalian cortex also use a semaphorin gradient for neurite guidance, the assay is based on evolutionary conserved cellular mechanisms, supporting its relevance for cortical development.

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Copper and cadmium administration induce toxicity and oxidative stress in the marine flatworm Macrostomum lignano

Cited by 16 publications

References 80 publications

Geochemical factors affecting the solubility of copper in seawater

Geochemical factors affecting the solubility of copper in seawater

The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity

Looking at Developmental Neurotoxicity Testing from the Perspective of an Invertebrate Embryo

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