Copper and ceruloplasmin (Cp) concentrations during the acute inflammatory process in the rat

Conforti, Anita; Franco, L.; Milanino, R.; Velo, Giampaolo

doi:10.1007/bf01965394

Cited by 38 publications

(18 citation statements)

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“…The early increase in plasma copper level, which persists throughout the study, and the absence of early increase in liver copper levels confirm some other reports [12][13][14]. Contrary to other authors who performed assays at specific periods of time in various inflammatory states [60,61], we did not find any correlation over the whole study period between plasma copper and acute phase reactants, especially ceruloplasmin. This suggests that the increase in non-ceruloplasmin bound copper is higher than that in ceruloplasmin bound element, particularly after 12 days, when plasma copper levels were rather high.…”

Section: Discussionsupporting

confidence: 51%

Changes in zinc, copper and selenium status during adjuvant-induced arthritis in rats

et al. 1988

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Trace elements such as zinc, copper and selenium are involved in the pathogenesis of inflammatory diseases. In order to obtain more information about the overall movements of these minerals during the evolution of an experimental chronic inflammatory process, trace element levels were determined in five body compartments of the rat at several time intervals after induction of adjuvant arthritis. Rapid and significant changes in plasma zinc and copper levels and in liver zinc levels were observed. These modifications occurred as early as those in biochemical parameters of inflammation such as serum fibrinogen and ceruloplasmin, and preceded the appearance of any clinical symptom of the disease. Inverse correlations were found between plasma zinc levels and these two biochemical indices. Other modifications in trace element levels were observed two weeks after disease induction, the most important being a considerable increase in liver copper levels. Although food intake of affected animals decreased with the progression of the disease, there was no evidence of depletion in zinc and copper levels over the study period. A redistribution of body zinc between different biological compartments (mainly plasma and liver) occurred simultaneously with an accumulation of copper in several organs. The decreasing selenium status of animals was not clearly related to the inflammatory process.

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Section: Discussionsupporting

confidence: 51%

Changes in zinc, copper and selenium status during adjuvant-induced arthritis in rats

et al. 1988

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“…The situation is more complex for Cu as increases in Cu levels in the serum or at sites of infection are usually associated with an increase in the production of ceruloplasmin (95,96). Ceruloplasmin is a ferroxidase and is a key component of Fe homeostasis, but it is also a major Cu store in cells as it binds six Cu ions in the active site.…”

Section: Discussionmentioning

confidence: 99%

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

Djoko¹,

Ong²,

Walker

et al. 2015

Journal of Biological Chemistry

345

268

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Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the decreased survival of bacterial pathogens with impaired Cu and/or Zn detoxification systems in phagocytes and animal models of infection has been reported. Consequently, a model has emerged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pathogens. This review describes and assesses the potential role for Cu and Zn intoxication in innate immune function and their direct bactericidal function.Six first row d-block metal ions, manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), and zinc (Zn), are essential micronutrients in living organisms. Investigations and discussions of the roles of these trace metals in biology often relate to their acquisition, storage, and incorporation into enzymes. However, conditions where these metal ions are present in excess or are found in the wrong location, resulting in toxicity, have also been described. Thus, there are also systems that sequester, export, and detoxify excess trace metal ions. Today, the concept of trace metal homeostasis, in which various cellular actions maintain the fine balance between nutrition and toxicity, is well developed.Recently, the concept of "nutritional immunity" has emerged in the context of host defense against pathogens. This envisages a role for mechanisms that protect the host from invading pathogens by restricting their ability to acquire key transition metal ions. One example involves lipocalin, which binds siderophores and thereby prevents Fe acquisition by bacterial pathogens (1). Another is calprotectin, which restricts acquisition of Zn or Mn (2). However, what if the host was able to harness the toxic properties of transition metal ions and use them as bactericides? This review explores the evidence for an antimicrobial role for Cu and Zn in the host defense against bacterial pathogens.

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“…Nevertheless we are just at the beginning of understanding the value of such therapies, and further work is needed to clarify many sides of the problem which are still largely obscure. A brief summary of the future trends in research developments that most urgently need to be explored, and of which a more circumstantial rationale has been recently published [24], may include: 1) a quantitative evaluation of copper and zinc metabolism in models of chronic inflammation of which the adjuvant arthritis in the rat may be the most appropriate one; 2) a quantitative evaluation, in both chronic as well as acute inflammatory processes, of the copper and zinc status within the inflamed site; 3) a qualitative estimate (carried out at least in those compartments in which quantitative variations have been observed) aimed at recognizing the most important "chemical species" that, beside ceruloplasmin [25] are involved in the changes induced by the inflammatory process in copper and/or zinc metabolism; 4) an investigation directed to obtain more information about the mechanism(s) of action through which copper and zinc, both endogenous as well as exogenous, may operate in controlling the development of the inflammatory reaction; 5) finally, since the level of intestinal metallothionein (MT) seems to play a major role in the regulation of intestinal absorption of both zinc and copper [26][27][28][29], it would also be useful to establish whether or not the induction of an inflammatory process could modify the metabolism of intestinal MT. …”

Section: Discussionmentioning

confidence: 99%

Copper and zinc status during acute inflammation: studies on blood, liver and kidneys metal levels in normal and inflamed rats

et al. 1986

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The concentrations of copper and zinc in plasma, blood cells, liver and kidneys were determined in a study performed on normal female rats, and in female rats with carrageenan induced pleurisy. In the normal rat, the total amount of both metals increases, from 51 to 79 days of age, in all the compartments examined. This increase was mostly, and in some case exclusively, dependent upon the growth of the animal, although high individual and day to day variations in both copper and zinc values were observed in all the compartments studied. In the blood of inflamed rats a statistically significant increase in copper was measured during the crucial hours of the experiment (i.e. from 6 to 72 h); over 90% of the increase found was attributable to variations in plasma copper concentration values. In the liver of inflamed rats a statistically significant increase in zinc was measured at 6, 22 and 48 h after the carrageenan injection. The induction of the acute non-infective inflammatory process did not cause quantitative changes of both copper and zinc in all the other compartments considered in the present study. These results seem to suggest that, during acute inflammation, the organism increases its requirement for copper and zinc, and that this demand is fulfilled by enhanced intestinal absorption and/or decreased intestinal excretion of both metals.

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Copper and ceruloplasmin (Cp) concentrations during the acute inflammatory process in the rat

Cited by 38 publications

References 31 publications

Changes in zinc, copper and selenium status during adjuvant-induced arthritis in rats

Changes in zinc, copper and selenium status during adjuvant-induced arthritis in rats

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

Copper and zinc status during acute inflammation: studies on blood, liver and kidneys metal levels in normal and inflamed rats

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