Copper and Human Health- A Review

Karim, Nasim

doi:10.51985/jbumdc2018046

Cited by 30 publications

(12 citation statements)

References 44 publications

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“…Nickel requirements by humans have been estimated between 5.00 and 50.00 μg per day (EMEA 2008). According to Karim (2018), copper is an essential trace element. Its deficiency is involved in the etiology of many diseases of gastrointestinal and neurological systems as well as affects function of heart, pancreas etc.…”

Section: Resultsmentioning

confidence: 99%

Study on the impact of pumpkin seed flour on mineral content of wheat bread

Zlateva

Stefanova

Chochkov

et al. 2022

FSAB

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The incorporation of various flours from seeds into wheat bread can improve its nutritional value. Pumpkin seeds flour can be a good alternative for nutritional enrichment of food products because of its high content of protein, oil, dietary fibers and minerals. The aim of the present study was to investigate the effect of pumpkin seed flour (PSF), added in the amount of 5% and 10% by the weight of flour, on the content of minerals in wheat bread. It was found that wheat bread with pumpkin seed flour had a significantly higher levels of minerals as compared to the control; except for sodium. Moreover, the minerals content of bread was found to increase markedly with increasing the substitutions ratio. The most pronounced was the effect of enrichment on the content of iron - at the addition of 10% PSF it was 8,98 mg/kg, which is 6,7 times higher than the control sample (1,34 mg/kg). A considerable increase in the content of magnesium and phosphorus was also found. Regarding the microelements, the amount of zinc increased most significantly – 5,09 mg/kg in the control sample; 9,27 mg/kg into the sample with 5% PSF; 12,7 mg/kg in the bread with 10% PSF added.

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Section: Resultsmentioning

confidence: 99%

Study on the impact of pumpkin seed flour on mineral content of wheat bread

Zlateva

Stefanova

Chochkov

et al. 2022

FSAB

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“…At a very high concentration, Cr compounds can initiate carcinogenesis [27]. Long-term Cu exposure causes blood and liver problems, as well as neurological damage [28]. High Ni exposure can cause allergic reactions, skin and organ damage, and immune dysfunction [29].…”

Section: Levels and Health Risks Of Heavy Metals In The Water Samplesmentioning

confidence: 99%

Human Safety Evaluation of Heavy Metals, Physicochemical Parameters, and Microorganisms in Lagoon Water at Ikorodu Lighter Terminal in Lagos, Nigeria

Yahaya

Balogun

Danlami

et al. 2023

Trop. Aqua. Soil Pollut.

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Ikorodu Lighter Terminal is an important lagoon port in Lagos, Nigeria. However, the intense anthropogenic activities that take place around the port could potentially pollute the water. This study assessed the safety of human exposure to the water around the port. Samples of the water were assayed for physicochemical parameters, namely: electrical conductivity, biochemical oxygen demand (BOD), total suspended solids (TSS), total dissolved solids (TDS), pH, turbidity, hardness, calcium, chloride, sulphate, nitrite, and phosphate. Moreover, heavy metals, including lead, manganese, copper, cadmium, nickel, and chromium, were analyzed, and their values were used to estimate potential health risks. Also assayed was the presence of microorganisms. The water samples had non-permissible levels of nitrite, oil and grease, and BOD. The concentrations of the heavy metals as well as their average daily ingestion and average daily dermal exposure were within the tolerable limits, except Ni. However, their hazard quotient and carcinogenic risk via ingestion and dermal contact exceeded the tolerable limits. Safe levels of bacteria, coliforms, and fungi were detected in the water. Based on these results, the water may expose users to health hazards. There is a need for policies geared towards the safety of human exposure to the water.

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“…The persistent presence of copper, its resistance to biodegradation, and its potential to trigger the formation of harmful free radicals, teratogenic effects, and irregularities in chromosomal structure, all contribute to significant environmental and health risks (Mitra et al, 2022;Lawrence and Hemingway, 2008). Ingesting excessive amounts of copper has been associated with a range of negative health outcomes, including intravascular hemolysis, liver cirrhosis, rapid heart rate, and acute kidney failure (Karim, 2018). Release of excessive copper sulphate into water sources can seriously harm the quality of the water.…”

Section: Introductionmentioning

confidence: 99%

Induction of micronuclei in blood and histopathological alterations in gill, kidney and liver of Channa punctatus (Bloch, 1793) exposed to copper sulphate

Kumari,

Kumar,

Trivedi

et al. 2024

JANS

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Copper is one of the most toxic metals to fish and causes cytotoxic, mutagenic and carcinogenic effects. The accumulation of copper in an aquatic environment directly impacts man and the aquatic ecosystem. The present study aimed to determine the effect of copper sulphate (CuSO4) accumulation on the induction of micronuclei in blood and histological changes in kidney and liver of the fish Channa punctatus. The test chemical LC50 was determined after 96 hours during the first experiment. Later in the second experiment, the test animal was exposed to three sub-lethal concentrations of CuSO4 [0.1 mg/l (96 h-LC50/40), 0.2 mg/l (96 h-LC50/20) and 0.4 mg/l (96 h-LC50/10)]. Physico chemical parameters of the test medium, such as pH, temperature, hardness, alkalinity, and dissolved oxygen, were observed throughout the experiment, and all values were within the ranges necessary for the fish's survival. At intervals of 7, 14, 21, and 28 days, the control (without any test chemical) and copper sulphate exposed Groups' blood, liver, kidney, and gill tissues were taken to evaluate changes in genotoxic and histological parameters. Micronuclei (MN) induction and nuclear abnormalities (NAs) were observed at regular intervals. After 28 days, the MN frequency in Groups 1, 2, 3, and 4 was 0.78±0.006, 8.40±0.052, 10.37±0.098 and 10.90±0.024 respectively. A significant (P< 0.05) rise in MN frequencies and NAs indicated fish erythrocytes' DNA damage. Histological analysis of the liver, kidney, and gills revealed serious tissue injury such as necrosis, vacuolization, and degeneration after 28 days in the exposed Groups. The present study observed changes due to genotoxicity and histology, giving the most comprehensive understanding of CuSO4 stress on the fish C. punctatus and its risks to human health.

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Copper and Human Health- A Review

Cited by 30 publications

References 44 publications

Study on the impact of pumpkin seed flour on mineral content of wheat bread

Study on the impact of pumpkin seed flour on mineral content of wheat bread

Human Safety Evaluation of Heavy Metals, Physicochemical Parameters, and Microorganisms in Lagoon Water at Ikorodu Lighter Terminal in Lagos, Nigeria

Induction of micronuclei in blood and histopathological alterations in gill, kidney and liver of Channa punctatus (Bloch, 1793) exposed to copper sulphate

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