Copper and inflammation

Whitehouse, M. W.; Walker, WR

doi:10.1007/bf01972407

Cited by 67 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exogenous copper and copper complexes are known to have anti-inflammatory activity (30). Increased serum copper level has been found in rheumatoid arthritis (31) and in adjuvant arthritic rats (32), providing defini tive evidence for the involvement of endoge nous copper in inflammatory disease.…”

Section: Discussionmentioning

confidence: 99%

Suppression of Adjuvant Arthritis in Rats by Cholesterol

Kunitomo

Yamaguchi

Futagawa

et al. 1987

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

Abstract-Dietary cholesterol suppressed adjuvant arthritis, a chronic inflammatory disease, in rats, but did not significantly affect carrageenin edema, an acute inflammation.When rats were fed a high-cholesterol diet beginning 10 days before injection of adjuvant, the development of the adjuvant-induced arthritis was greatly suppressed.Cholesterol feeding prevented hypertrophy of the adrenal gland in arthritic rats, but had little influence on the serum corticosterone level. A sig nificant positive correlation was observed between the adrenal weight and the severity of the arthritis.These findings suggest that the effect of cholesterol feeding is not due to increased adrenal sterol synthesis.Dietary cholesterol also prevented hypertrophy of the spleen, but had no effect on atrophy of the thymus in adjuvant treated rats. Cholesterol-fed rats showed a significant decrease in the serum lipid peroxide level and a significant increase in the serum copper level. Adjuvant treatment not only enhanced hypercholesterolemia produced by cholesterol feeding, but also the level of free cholesterol in serum. These results suggest that dietary cholesterol may exert some effect on the immune response through changes in spleen and liver functions.

show abstract

Section: Discussionmentioning

confidence: 99%

Suppression of Adjuvant Arthritis in Rats by Cholesterol

Kunitomo

Yamaguchi

Futagawa

et al. 1987

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…On the other hand, pulverized metallic copper and simple copper salts, like basic copper acetate and copper(II) sulphate, were used 3500 years ago for treating chronic inflammation of the eye [9]; moreover, the copper bracelet, an old anti-arthritic remedy belonging to the popular tradition, has been recently evaluated on a scientific ground revealing to possess a potential therapeutic value which cannot be entirely neglected [10,11]. In summary, these observations show that copper is active as an anti-inflammatory agent in chronic conditions in man and animals, and also indicate that the therapeutic effect observed may be independent of the chemical form of copper administered.…”

Section: Copper In Chronic Inflammation (A) Therapeutic Value Of Coppmentioning

confidence: 99%

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

et al. 1985

View full text Add to dashboard Cite

Acute and chronic inflammations are characterized, among other features, by changes in the metabolism of copper and by a widespread responsiveness to the therapy with copper-containing molecules. The exact map of inflammation-induced copper movements as well as the role played by the metal in the pathogenesis of inflammatory disorders are, however, far from being clear, and this is especially true in the case of chronic processes. Nevertheless the present knowledge suggests that the "copper approach' may provide a new way for coping with the problem of anti-inflammatory/anti-arthritic therapies. The administration of exogenous copper, and the in vivo manipulation of the endogenous metal levels are proposed as two possible therapeutic strategies, not necessarily mutually exclusive. For a better understanding of the value of such an approach, further research work is needed, especially to attain a more detailed know-how on the involved chemical forms, distribution and functions of copper in both normal as well as inflamed organisms.

show abstract

“…The value of copper administration in the treatment of rheumatic diseases has been suggested for more than 1000 years [1] and more recently confirmed by clinical studies showing that copper complexes possess antiinflammatory effects both in animals [2] and in man [3]. Dietary copper restriction in the rat significantly increases the acute inflammatory reaction [4] but apparently inhibits the development of complete adjuvant arthritis [5].…”

Section: Introductionmentioning

confidence: 99%

Changes in zinc, copper and selenium status during adjuvant-induced arthritis in rats

et al. 1988

View full text Add to dashboard Cite

Trace elements such as zinc, copper and selenium are involved in the pathogenesis of inflammatory diseases. In order to obtain more information about the overall movements of these minerals during the evolution of an experimental chronic inflammatory process, trace element levels were determined in five body compartments of the rat at several time intervals after induction of adjuvant arthritis. Rapid and significant changes in plasma zinc and copper levels and in liver zinc levels were observed. These modifications occurred as early as those in biochemical parameters of inflammation such as serum fibrinogen and ceruloplasmin, and preceded the appearance of any clinical symptom of the disease. Inverse correlations were found between plasma zinc levels and these two biochemical indices. Other modifications in trace element levels were observed two weeks after disease induction, the most important being a considerable increase in liver copper levels. Although food intake of affected animals decreased with the progression of the disease, there was no evidence of depletion in zinc and copper levels over the study period. A redistribution of body zinc between different biological compartments (mainly plasma and liver) occurred simultaneously with an accumulation of copper in several organs. The decreasing selenium status of animals was not clearly related to the inflammatory process.

show abstract

Copper and inflammation

Cited by 67 publications

References 24 publications

Suppression of Adjuvant Arthritis in Rats by Cholesterol

Suppression of Adjuvant Arthritis in Rats by Cholesterol

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

Changes in zinc, copper and selenium status during adjuvant-induced arthritis in rats

Contact Info

Product

Resources

About