Copper and Zinc as Potential Biomarkers of Mood Disorders and Pandemic Syndrome

Świądro, Magdalena; Ordon, Klaudia; Herman, Małgorzata; Dudek, Dominika; Wietecha‐Posłuszny, Renata

doi:10.3390/molecules27010091

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Siwek et al reported that TBARS levels showed increased oxidative stress in the acute phase of bipolar disorder [7]. Microelements, including zinc and copper, which are involved in neuroinflammation [8], have been studied in mood disorders and copper levels were found to be low, while zinc levels were found to be higher in the control group [9]. The increase in peripheral inflammation marker levels and high incidence of some inflammatory and immune diseases in patients with BD support this hypothesis [10,11].…”

Section: Introductionmentioning

confidence: 92%

Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior

Sırlıer Emir,

Yıldız,

Kazğan Kılıçaslan

et al. 2023

Medicina

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Background and Objectives: This study aimed to examine the function of various inflammation parameters and their interactions in the pathology of Bipolar disorder (BD) and to assess whether they could be biomarkers in the relationship between criminal behavior and BD. Materials and Methods: Overall, 1029 participants, including 343 patients with BD who have committed offenses, 343 nonoffending patients with BD, and 343 healthy controls, were included in this retrospective study. Neutrophil, lymphocyte, monocyte, and platelet counts; high-density lipoprotein (HDL-c) levels; systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), neutrophil to high-density lipoprotein ratio (NHR), lymphocyte to high-density lipoprotein ratio (LHR), monocyte to high-density lipoprotein ratio (MHR), platelet to high-density lipoprotein ratio (PHR) were measured. Results: Significant differences were observed between the groups in terms of SII, SIRI, NHR, LHR, MHR, PHR, neutrophil, and monocyte values (p < 0.001). The lymphocyte counts were significantly higher in the patients with BD who committed offenses (p = 0.04). The platelet counts were significantly lower in the patients with BD who committed offenses compared to nonoffending patients with BD (p = 0.015). The HDL-c levels were significantly lower in the patients with BD who have committed offenses than those of nonoffending patients with BD (p < 0.001). Bipolar disorder, not receiving active psychiatric treatment, having a diagnosis of bipolar manic episodes, and having low platelet and HDL values constitute a risk of involvement in crime. Conclusions: The present study emphasizes the role of systemic inflammation in the pathophysiology of patients with BD with and without criminal offenses and the relationship between inflammation and criminal behavior.

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Section: Introductionmentioning

confidence: 92%

Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior

Sırlıer Emir,

Yıldız,

Kazğan Kılıçaslan

et al. 2023

Medicina

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“…Copper stimulates the production of ROS that are involved in oxidative stress that damages DNA, proteins, and lipids [225]. Further, it should be noted that ceruloplasmin, a major copper transporter in the human organism, was observed to be increased in patients suffering from mood disorders [226]. Although the role of ceruloplasmin in depression remains uncertain, elevated serum levels of ceruloplasmin may indicate the potential significance of copper ions in mood disorders [227][228][229].…”

Section: Coppermentioning

confidence: 99%

Trace Elements Levels in Major Depressive Disorder—Evaluation of Potential Threats and Possible Therapeutic Approaches

Baj,

Bargieł,

Cabaj

et al. 2023

IJMS

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The multifactorial etiology of major depressive disorder (MDD) includes biological, environmental, genetic, and psychological aspects. Recently, there has been an increasing interest in metallomic studies in psychiatry, aiming to evaluate the role of chosen trace elements in the MDD etiology as well as the progression of symptoms. This narrative review aims to summarize the available literature on the relationship between the concentration of chosen elements in the serum of patients with MDD and the onset and progression of this psychiatric condition. The authors reviewed PubMed, Web of Science, and Scopus databases searching for elements that had been investigated so far and further evaluated them in this paper. Ultimately, 15 elements were evaluated, namely, zinc, magnesium, selenium, iron, copper, aluminium, cadmium, lead, mercury, arsenic, calcium, manganese, chromium, nickel, and phosphorus. The association between metallomic studies and psychiatry has been developing dynamically recently. According to the results of current research, metallomics might act as a potential screening tool for patients with MDD while at the same time providing an assessment of the severity of symptoms. Either deficiencies or excessive amounts of chosen elements might be associated with the progression of depressive symptoms or even the onset of the disease among people predisposed to MDD.

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“…Zn, Mg and Cu were suggested to be involved in depressive disorders and proposed as a potential clinical marker for these conditions [36][37][38]. This was based on many reports indicating significant changes in blood levels of these elements during a depressive episode [18,39,40].…”

Section: Alterations In Element Concentrations In the Serum And Brainmentioning

confidence: 99%

Chemical Element Profiling in the Sera and Brain of Bipolar Disorders Patients and Healthy Controls

Sampath

Singh

Pelov

et al. 2022

IJMS

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Bipolar Disorder (BD) is a severe recurrent affective mood disorder characterized by a wide range of lifelong mood swings, varying between depressive and manic states. BD affects more than 1% of the world’s population irrespective of nationality, ethnic origin, or socioeconomic status and is one of the main causes of disability among young people, leading to cognitive and functional impairment and raised mortality, particularly death by suicide. Trace elements play a vital role in many biochemical and physiological processes. Compelling evidence shows that element toxicity might play a crucial role in the onset and progression of neurodegenerative disorders, but their involvement in mood disorders has been scarcely studied. In the present investigation, we determined the concentration of 26 elements in the serum of BD patients before and after treatment and in postmortem brain samples from BD patients and compared them with matched controls. The only element that was reduced significantly in the serum following treatment was vanadium (V). Furthermore, the concentration of Al, B, Cu, K, Mg and V were significantly lower in the pre-frontal cortex of BD patients compared with those of the controls. A comparison of Spearman’s rank correlation coefficients between the elements in the serum and brain of BD patients and control groups pointed to boron and aluminum as being involved in the disease. These results suggest that there is a disturbance in the elements’ homeostasis and the inter-elements’ relationship in the brain of BD patients and advocate a thorough examination of the possible involvement of chemical elements in different stages of the disease.

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Copper and Zinc as Potential Biomarkers of Mood Disorders and Pandemic Syndrome

Cited by 8 publications

References 18 publications

Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior

Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior

Trace Elements Levels in Major Depressive Disorder—Evaluation of Potential Threats and Possible Therapeutic Approaches

Chemical Element Profiling in the Sera and Brain of Bipolar Disorders Patients and Healthy Controls

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