Copper and Zinc levels in normal and malignant tissues

Margalioth, Ehud J.; Schenker, Joseph G.; Chevion, Mordechai

doi:10.1002/1097-0142(19830901)52:5<868::aid-cncr2820520521>3.0.co;2-k

Cited by 264 publications

(179 citation statements)

References 20 publications

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“…Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). On the other hand, it is well known that either an excess or a defi ciency of certain trace metals can lead to biological disorders.…”

Section: Discussionmentioning

confidence: 99%

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Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

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Abstract:Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones infl uence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively.These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre-and postoperative serum Cu level was signifi cantly higher when compared to control group (p<0.05). Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre-and postoperative serum Cu level was significantly lower than in the control group (p<0.05).Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group (Tab. 1, Ref. 18 Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2). Cu is important for the activity of the enzyme superoxide dismutase (SOD). Changes in the activity of this enzyme are consistent with the Cu serum levels (3). Cu was shown to be essential for cell division both in normal and cancerous tissue (4, 5). Although copper is an essential element for human and animals, a high concentration of Cu (above normal) could induce growth proliferation and cancer by damaging DNA with toxic free hydroxyl radicals (6).The present study was undertaken to investigate correlation of Cu serum levels in benign and malign thyroid diseases before and after surgery compared to controls. Materials and methodsThis is an age-and sex-matched case-control study, conducted at the Department of Medical Biochemistry of Celal Bayar University of Medicine and the Department of General Surgery of Ankara Oncology Hospital, Ankara, Turkey. The study was approved by the hospital Ethical committee. All the patients and the volunteers involved in the study have given informed consent. PatientsRecruitment of subjects was performed by convenience sampling at outpatient General Surgery Clinic of Oncology Hospital, Turkey by trained physicians. 47...

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Section: Discussionmentioning

confidence: 99%

“…They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2).…”

mentioning

confidence: 99%

Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

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“…Serum zinc levels are increased in melanoma patients (Ros-Bullon et al, 1998) but more often, reduced serum zinc levels are reported in breast (Sharma et al, 1994;Yucel et al, 1994), gallbladder (Gupta et al, 2005), lung (Diez et al, 1989;Issell et al, 1981), Hodgkin's disease (Cunzhi et al, 2001), colorectal (Gupta et al, 1993), neck (Buntzel et al, 2007), leukemia (Zuo et al, 2006) and thyroid (Al-Sayer et al, 2004) cancer patients. Elevated zinc levels in malignant tissues are observed in breast (Margalioth et al, 1983), intestinal (Kucharzewski et al, 2003), metastatic nasopharyngeal (Bay et al, 1997) cancers but are decreased in kidney carcinoma tissues (Margalioth et al, 1983). It is also high in bone marrow of patients with non-Hodgkin lymphomas (Schmitt et al, 1993).…”

Section: Association Of Zinc With Prostate Cancermentioning

confidence: 85%

Zinc Supplementation and Prostate Cancer

Wong¹,

AbuBakar²

2011

Prostate Cancer - From Bench to Bedside

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“…The distribution of copper and its homeostasis plays a major role in many biological processes 41 and this is facilitated by the work of metal transporters and chaperones 42 , 43 & 44 . Disruption in pathways that transport copper can cause major damages in the form of metallostasis found in tumors 45 . The pathway is regulated by copper homeostasis genes and recent transcriptome analysis of copper homeostasis genes have shown the upregulation of SLC31A1, SCO and COX11 in colorectal cancer cases 46 .…”

Section: Sco1-wnt10b-x Combinationsmentioning

confidence: 99%

Revealing ETC-1922159 Affected Unknown 3<em><sup>rd</sup></em> order WNT10B-X-X Combinations, in Silico

Sinha¹

2017

Preprint

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WNT10B belongs to the family of WNT proteins that are implicated in a range of phenomena that are affected by the Wnt signaling pathway. Recent studies have shown that WNT10B plays a role in colorectal cancer. WNTs have been found to directly affect the stemness of the tumor cells via regulation of ASCL2. Switching off the ASCL2 literally blocks the stemness process of the tumor cells and vice versa. Furthermore, recent findings suggest BVES to be highly suppressed in malignancies and in vitro deletions of BVES show higher Wnt signaling activity to induce stemness. WNT10B was found to be highly expressed in such cases. Often, in biology, we are faced with the problem of exploring relevant unknown biological hypotheses in the form of myriads of combination of factors that might be affecting the pathway under certain conditions. For example, WNT10B-ASCL2 is one such 2 nd order combination whose relation needs to be tested under the influence of recently developed porcupine-WNT inhibitor ETC-1922159. The inhibitor is known to suppress PORCN (porcupine) and thus inhibit a range of oncogenes known to be directly or indirectly affected by the Wnts. In a recent unpublished work in bioRxiv, Sinha 1 , we had the opportunity to rank these unknown biological hypotheses for down regulated genes at 2 nd order level after the drug was administered. The in silico observations showed that the combination of WNT10B-ASCL2 was assigned a relatively lower rank, thus validating the pipeline's efficacy with the confirmed wet lab experiment that indicate that both WNT10B and ASCL2 were down regulated after treatment in cancer cells. Here, we take one step further by in silico analysis of the 3 rd order combinations of WNT10B-X-X (X can be known or unknown factor), from a range of 100 randomly picked down regulated genes after ETC-1922159 treatment. The pipeline uses the density based HSIC (Hilbert Schmidt Information Criterion) sensitivity index with an rbf (radial basis function) kernel, which is known to be highly effective in sensitivity analysis. Various unknown/unexplored/untested 3 rd order biological hypotheses emerge some of which are confirmed in wet lab, while others need to be tested. The potential of such ranking is indispensable in the current era of search in a vast combinatorial forest. KEYWORDS -WNT pathway; porcupine inhibitor ETC-1922159; sensitivity analysis; colorectal cancer; unknown biological hypotheses; combinatorial search space; support vector ranking Conference, from 6-11 August 2017, held Significance WNT10B belongs to the family of WNT proteins that are implicated in a range of phenomena that are affected by the Wnt signaling pathway. Recent studies have shown that WNT10B plays a role in colorectal cancer. Often, we are faced with the problem of exploring relevant unknown biological hypotheses in the form of myriads of combination of factors that might be involved in the pathway. The current work reveals at in silico level, the 3rd order WNT10B associated combinations that might be affected by the admin...

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Copper and Zinc levels in normal and malignant tissues

Cited by 264 publications

References 20 publications

Serum copper levels in benign and malignant thyroid diseases

Serum copper levels in benign and malignant thyroid diseases

Zinc Supplementation and Prostate Cancer

Revealing ETC-1922159 Affected Unknown 3<em><sup>rd</sup></em> order WNT10B-X-X Combinations, in Silico

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