Copper-catalyzed 1,2,2-trifunctionalization of maleimides with 1,7-enynes and oxime esters via radical relay/1,5-hydrogen-atom transfer

Abstract

We describe a novel 1,2,2-trifunctionalization of maleimides with 1,7-enynes and oxime esters through simultaneous construction of four C−C bonds and a C≡N bond in one pot based on the radical relay/1,5-hydrogen-atom transfer (HAT).

Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines

“…Therefore, numerous methods have been established to synthesize functionalized molecules in recent years. In addition, radical cascade reactions involving the 1,2-difunctionalization of alkyne have become a versatile tool in contemporary organic chemistry [ 11 , 12 , 13 , 14 ]. To date, the cyclization of alkynes toward the synthesis of cyclic compounds has been effectively investigated [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”