Copper‐Catalyzed 1,2‐Dicarbonylative Cyclization of Alkenes with Alkyl Bromides via Radical Cascade Process

Abstract

Herein, we developed a new procedure on 1,2dicarbonylative cyclization of 4-aryl-1-butenes with alkyl bromides. Using simple copper catalyst, two molecules of carbon monoxide were introduced into the double bond with the formation of four new CÀ C bonds and a new ring. Various α-tetralones and 2,3-dihydroquinolin-4-ones were formed in moderate to good yields.

Palladium-Catalyzed Coupling of Amides and Cyclopropanols for the Synthesis of γ-Diketones

“…[13][14][15][16] Tremendous efforts have therefore been devoted to the establishment of diverse synthetic pathways for access to this compound class. [17][18][19][20][21][22][23][24] Despite the progress, the synthetic protocols developed thus far can suffer from various drawbacks. The classical acyl anion-(Stetter type) and enolate-based methods are constrained by harsh reaction conditions and limited functional group tolerance.…”