Copper-catalyzed aerobic nitrogen-migration cyanation and oxygenation of unsaturated ketoximes via the CC bond cleavage: facile access to 4-oxobutanenitriles

Abstract

A new copper-catalyzed aerobic synthesis of 4-oxobutanenitriles by nitrogen-migration cyanation and oxygenation of γ,δ-unsaturated keto oximes at room temperature is developed. By means of the copper(0) powder catalyst, a nitrogen-migration...