Copper-catalyzed cross-dehydrogenative coupling of P(O)−H compounds with O-/S-nucleophiles

Lewis-acid-catalyzed phosphorylation of alcohols

“…Recently, a novel Brønsted-acid-catalyzed phosphorylation of o -hydroxybenzyl alcohol has been developed—leading to the synthesis of diphenylphosphonates from trialkylphosphites serving as starting materials and achieved using the phosphate-Michael addition reaction 14 ( Scheme 1d ). In addition, synthetic chemists have made remarkable progress in investigating methods for forming P–O bonds between P sources and alcohols in recent years, with examples of these methods including, the nucleophilic substitution reaction, 15 Atherton–Todd reaction, 16 cross-dehydrogenative coupling reaction 17 and electrophile reaction. 18 Our group focuses on the phosphorylation of ketones or aldehydes via the phospha-aldol-elimination (PAE) reaction catalyzed by Lewis acid or Brønsted acid.…”

Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones: access to γ-halo allylic phosphonates

“…Organophosphorus compounds are widely utilized in medicines, 1 agrochemicals 2 and functional materials, 3 and the synthesis of phosphorus functionalized chemicals has emerged as a significant research focus for chemists and pharmacologists. 4 The creation of allylic organophosphorus compounds has attracted special research efforts because such scaffolds can serve as building blocks to access a variety of functionalized organophosphorus compounds, through hydrogenation, 5 hydrofunctionalization 6 or difunctionalization, for example.…”