2024
DOI: 10.1002/adsc.202401198
|View full text |Cite
|
Sign up to set email alerts
|

Copper‐Catalyzed Dearomative Cyclization of Indolyl Ynamides for Synthesis of Pentacyclic Spiroindolines

Miao Xu,
Jia‐Tian Jiang,
Hao‐Xuan Dong
et al.

Abstract: The dearomatization of indoles with ynamides is a convenient access towards polycyclic spiroindolines, which can be initiated by α‐ and β‐additions of ynamides. Currently, the related β‐addition initiated dearomative cyclization requires noble‐metal catalyst or stoichiometric oxidant. Herein, we report a copper‐catalyzed dearomative cyclization of aryl‐substituted indolyl ynamides through regioselective β‐addition onto ynamides, providing pentacyclic spiroindolines in 81–97% yields with >25:1 diastereosele… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 62 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?