Copper‐Catalyzed Domino Halide Exchange‐Cyanation of Aryl Bromides.

Abstract

Nitriles Nitriles Q 0520Copper-Catalyzed Domino Halide Exchange-Cyanation of Aryl Bromides. -This offers a mild, simple, and improved method for the synthesis of aromatic nitriles. -(ZANON, J.; KLAPARS, A.; BUCHWALD*, S. L.; J.

Fabrication of Pd Nanoparticles Embedded C@Fe3O4 Core–Shell Hybrid Nanospheres: An Efficient Catalyst for Cyanation in Aryl Halides

“…Hence, low yield is obtained for aryl bromides in cyanation. Although the result is less satisfactory, we were able to obtain good yield by using iodide ion, which leads to catalysed production of aryl iodide from aryl bromide and its subsequent in situ cyanation, as reported by Buchwald et al, 74 and 0.2 mmol of KI is sufficient to promote the cyanation of aryl bromides. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 A wide variety of diversely substituted aryl halides underwent cyanation by this procedure to produce the corresponding nitriles ( Table 2, entries 5-6) substituted aryl iodides reacted readily.…”

Rapid ecosynthesis of TiO2@CuO@Chromite nanocatalyst for environmentally friendly applications: solventless cyanation of aldehydes and high efficient treatment of sewage waters

“…After monitoring by TLC, the obtained products were isolated by EtOAc, then dried, concentrated at reduced pressure and finally recrystallized. All obtained products were well known and their structure confirmed by comparison of their mp, IR, NMR data reported by previous works [18,[34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

“…Recently, usage of ecofriendly methods to introduce nitriles has been converted to a new gate in their synthesis. Some of these challenges were reduced by ligand-free green catalytic cyanation of aryl halides using K 4 Fe(CN) 6 as an absolutely safe cyanide source [13][14][15][16][17][18]. Reports on the aldehydes cyanation in order to obtain the aryl nitriles indicated the aforementioned drawbacks of the methods [19][20][21], thus introducing economic and safe methods to obtain the aryl nitriles is of great attention.…”

A highly efficient polymer‐anchored palladium(II) complex catalyst for hydrogenation, Heck cross‐coupling and cyanation reactions

“…Cyanation of aryl halides is a common and useful transformation in organic synthesis. In this reaction typical cyanide sources are KCN,61 Me 3 SiCN,62 NaCN63 and Zn(CN) 2 64. The utilization of these cyanide sources has numerous drawbacks as they are highly toxic and may contaminate the product mixture.…”