Copper-catalyzed enantioselective conjugate addition of dialkylzinc reagents to enones with new peptidyl phosphane ligands

Biologically inspired phosphino platinum complexes

“…In particular, amino acid derived ligands have been a focus for several reasons, including: the potential to impart chirality; [5][6][7] functional groups with which to control solubility [8]; and the potential to enhance the water solubility of the resulting metal complex [9,10]. Perhaps more importantly, the amino acid derived ligands can impart some of the features of enzymes, nature's catalysts which perform their respective reactions with great speed and selectivity.…”

Supramolecular PhanePhos-analogous ligands through hydrogen-bonding for asymmetric hydrogenation

“…The synthesis of the ligands was straightforward, employing conventional solution-phase peptide synthesis procedures 10,11 (for details see ESIw).…”

Bioinspired Catalyst Design and Artificial Metalloenzymes

“…[20] These systems were applied in copper-catalysed conjugate additions, achieving selectivities similar to those reported by Hoveyda et al Breit and co-workers also demonstrated that these phosphane ligands can form diphosphane ligands by homodimeric self-assembly of the peptides into helical structures through hydrogen bonding and pstacking (Scheme 2a). [21] These assemblies were applied in the rhodium-catalysed hydrogenation of protected amino acid precursors and dimethylitaconate reaching over 95 % ee for each substrate used.…”