Copper‐Catalyzed Fluoroamide‐Directed Remote C(sp³)‐H Bond Functionalization Through Intramolecular Hydrogen Atom Transfer

Abstract

Direct C‐H functionalization is an important strategy for the rapid synthesis of valuable organic molecules. Radical‐involved remote C(sp3)‐H functionalization based on hydrogen atom transfer (HAT) becomes an important method enabling selective direct transformation of C(sp3)‐H bonds at specific distal position(s). In the recent years, copper‐catalyzed fluoroamide‐directed remote C(sp3)‐H bond functionalization through intramolecular HAT has served as a robust and elegant strategy for the assembly of a variety of functionalized (sulfon)amides and related derivatives. This review focuses on the recent advances in this area. These transformations proceed effectively with high selectivities and good functional group compatibility under mild conditions.